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New Developments in NMR
New Applications of NMR in Drug Discovery and Development
Edited by
Leoncio Garrido;
Leoncio Garrido
Consejo Superior de Investigaciones Cientifica, Spain
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Nicolau Beckmann
Nicolau Beckmann
Novartis, Switzerland
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Hardback ISBN:
978-1-84973-444-8
PDF ISBN:
978-1-84973-766-1
Series:
New Developments in NMR
No. of Pages:
565
Publication date:
18 Jul 2013
About this book
This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods, many of which are not yet widely applied but are likely to provide new opportunities for drug design.
The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and their interactions with targets. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity.
Aimed at NMR spectroscopists, pharmacologists, imaging researchers and pharmaceutical scientists, this title is invaluable at putting NMR in context within its role in drug discovery and development. This resource is essential reading for those both new and already active in these areas.
New Applications of NMR in Drug Discovery and Development, The Royal Society of Chemistry, 2013.
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New Applications of NMR in Drug Discovery and Development
$224.00
Table of contents
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CHAPTER 1: New Applications of High‐Resolution NMR in Drug Discovery and Developmentp7-42ByMaría del Carmen Fernández‐Alonso;María del Carmen Fernández‐AlonsoSearch for other works by this author on:Jesús Jiménez‐BarberoJesús Jiménez‐BarberoSearch for other works by this author on:
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Chapter 2: Solid‐State NMR in Drug Discovery and Developmentp43-100ByFrederick G. VogtFrederick G. VogtProduct Development, GlaxoSmithKline plc.709 Swedeland Rd, King of Prussia, PA, 19406USAPresent address: Morgan, Lewis & Bockius LLP1701 Market St., Philadelphia, PA, 19103-2921USA[email protected]Search for other works by this author on:
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CHAPTER 3: High‐Resolution NMR‐Based Metabolic Profiling in Drug Discovery and Developmentp101-133ByNigel J. WatersNigel J. WatersSearch for other works by this author on:
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CHAPTER 4: In‐Cell NMR Spectroscopy to Study Protein–Drug Interactionsp134-161ByJacqueline D. Washington;Jacqueline D. WashingtonDepartment of ChemistryState University of New York at Albany, 1400 Washington Ave., Albany, NY 12222USA[email protected]Search for other works by this author on:David S. Burz;David S. BurzDepartment of ChemistryState University of New York at Albany, 1400 Washington Ave., Albany, NY 12222USA[email protected]Search for other works by this author on:Alexander ShekhtmanAlexander ShekhtmanDepartment of ChemistryState University of New York at Albany, 1400 Washington Ave., Albany, NY 12222USA[email protected]Search for other works by this author on:
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CHAPTER 5: Increased Sensitivity Using Cryogenic Radiofrequency Coils: Application to In Vivo Phenotyping of Micep165-183ByJ. Klohs;J. KlohsInstitute for Biomedical EngineeringETH & University of Zurich, 8093 ZurichSwitzerlandSearch for other works by this author on:A. Seuwen;A. SeuwenInstitute for Biomedical EngineeringETH & University of Zurich, 8093 ZurichSwitzerlandSearch for other works by this author on:A. Schröter;A. SchröterInstitute for Biomedical EngineeringETH & University of Zurich, 8093 ZurichSwitzerlandSearch for other works by this author on:D. Marek;D. MarekBruker BioSpin AGCH‐8117 FällandenSwitzerlandSearch for other works by this author on:M. RudinM. RudinInstitute for Biomedical EngineeringETH & University of Zurich, 8093 ZurichSwitzerlandInstitute of Pharmacology and ToxicologyUniversity of Zurich, 8052 ZurichSwitzerland[email protected]Search for other works by this author on:
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CHAPTER 6: Recent Developments of Contrast Agents, CEST and Low Fieldsp184-203ByS. Aime;S. AimeDepartment of Molecular Biotechnologies and Health SciencesUniversity of Torino, Molecular Imaging CenterVia Nizza 52, Torino, 10126, Italy[email protected]Search for other works by this author on:D. L. LongoD. L. LongoDepartment of Molecular Biotechnologies and Health SciencesUniversity of Torino, Molecular Imaging CenterVia Nizza 52, Torino, 10126, Italy[email protected]Search for other works by this author on:
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Chapter 7: Pharmacological fMRI in Drug Discovery and Developmentp204-229ByAlexandre Coimbra;Alexandre CoimbraClinical Imaging GroupEarly Clinical Development, Genentech, Inc.South San Francisco, CA, USASearch for other works by this author on:Richard Baumgartner;Richard BaumgartnerBiometrics, Merck Research LaboratoriesMerck & Co., Inc.Rahway, NJ, USASearch for other works by this author on:Adam J. SchwarzAdam J. SchwarzTranslational MedicineLilly Research Laboratories, Eli Lilly & Co.Indianapolis, IN, USA[email protected]Search for other works by this author on:
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CHAPTER 8: In Vivo Proton MR Spectroscopy: Animal and Human Applications at High Fieldsp230-251
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CHAPTER 9: Hyperpolarization: Concepts, Techniques and Applicationsp252-272ByArnaud CommentArnaud CommentÉcole Polytechnique Fédérale de LausanneInstitute of Physics of Biological System, SB‐IPSB GR‐CO, Station 6, CH‐1015, LausanneSwitzerland[email protected]Search for other works by this author on:
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CHAPTER 10: Combined PET/MRI for Improving Quantitative Imagingp273-292ByTim D. FryerTim D. FryerWolfson Brain Imaging Centre, Department of Clinical Neurosciences, Hills RdUniversity of CambridgeCambridgeCB2 0QQUK[email protected]Search for other works by this author on:
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CHAPTER 11: Magnetic Resonance‐Based Cell Imaging Using Contrast Media and Reporter Genesp293-329ByGreetje Vande Velde;Greetje Vande VeldeBiomedical MRI Unit and Molecular Small Animal Imaging Center, Department of Imaging and Pathology, O&N1, bus 505Katholieke Universiteit Leuven, Herestraat 49, B‐3000LeuvenBelgium[email protected]Search for other works by this author on:Uwe HimmelreichUwe HimmelreichBiomedical MRI Unit and Molecular Small Animal Imaging Center, Department of Imaging and Pathology, O&N1, bus 505Katholieke Universiteit Leuven, Herestraat 49, B‐3000LeuvenBelgium[email protected]Search for other works by this author on:
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CHAPTER 12: Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challengesp333-360ByJohn C. WatertonJohn C. WatertonBiomedical Imaging InstituteThe University of Manchester, Manchester Academic Health Sciences Centre, Oxford Road, Manchester, M13 9PTUK[email protected]Personalised Healthcare & BiomarkersAstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TGUK[email protected]Search for other works by this author on:
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CHAPTER 13: In Vivo MRI/S for the Safety Evaluation of Pharmaceuticalsp361-375ByPaul D. Hockings;Paul D. HockingsAstraZeneca R&DPHB In Vivo Biomarkers, 43183 MölndalSwedenMedTech WestChalmers University of Technology, 41296 GothenburgSwedenSearch for other works by this author on:Helen PowellHelen PowellSearch for other works by this author on:
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CHAPTER 14: Applications of MRI and MRS in Cartilage Therapeutics and Tissue Engineeringp376-404ByDavid A. Reiter;David A. ReiterClinical Research Branch, National Institutes of HealthNational Institute on Aging, 3001 S. Hanover Street, 5th floor, Baltimore, MD 21225USASearch for other works by this author on:Richard G. SpencerRichard G. SpencerMagnetic Resonance Imaging and Spectroscopy Section, National Institutes of HealthNational Institute on Aging, 3001 S. Hanover Street, 5th floor, Baltimore, MD 21225USA[email protected]Search for other works by this author on:
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CHAPTER 15: Applications of Magnetic Resonance Spectroscopy to Psychiatric Disordersp405-421ByRichard A. KomoroskiRichard A. KomoroskiCenter for Imaging Research and Departments of Psychiatry & Behavioral Neuroscience and Biomedical Engineering, College of Medicine, University of Cincinnati231 Albert Sabin WayCincinnati, Ohio 45267‐0583, USA[email protected]Search for other works by this author on:
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CHAPTER 16: Structural Magnetic Resonance Imaging Biomarkers in Neurodegenerative Diseasep422-440ByLinda K. McEvoy;Linda K. McEvoyDepartment of RadiologyUniversity of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093USASearch for other works by this author on:Dominic Holland;Dominic HollandDepartment of NeurosciencesUniversity of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093USA[email protected]Search for other works by this author on:Anders M. DaleAnders M. DaleDepartment of RadiologyUniversity of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093USADepartment of NeurosciencesUniversity of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093USA[email protected]Search for other works by this author on:
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CHAPTER 17: Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Developmentp441-471ByNicolau Beckmann;Nicolau BeckmannNovartis Institutes for BioMedical Research, Global Imaging GroupCH‐4056 BaselSwitzerlandSearch for other works by this author on:Alexandre Trifilieff;Alexandre TrifilieffNovartis Institutes for BioMedical Research, Respiratory Diseases DepartmentCH‐4056 BaselSwitzerlandSearch for other works by this author on:Christine Egger;Christine EggerNovartis Institutes for BioMedical Research, Global Imaging GroupCH‐4056 BaselSwitzerlandBiocenter of the University of BaselCH‐4056 BaselSwitzerlandSearch for other works by this author on:Yannick CrémillieuxYannick CrémillieuxSearch for other works by this author on:
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Chapter 18: Cardiovascular Magnetic Resonancep472-489ByAlex Pitcher;Alex PitcherOxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe HospitalUniversity of Oxford, Headley Way, OxfordUK[email protected]Search for other works by this author on:Theodoros D. Karamitsos;Theodoros D. KaramitsosOxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe HospitalUniversity of Oxford, Headley Way, OxfordUK[email protected]Search for other works by this author on:Jürgen E. Schneider;Jürgen E. SchneiderOxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe HospitalUniversity of Oxford, Headley Way, OxfordUK[email protected]Search for other works by this author on:Stefan NeubauerStefan NeubauerOxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe HospitalUniversity of Oxford, Headley Way, OxfordUK[email protected]Search for other works by this author on:
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CHAPTER 19: Magnetic Resonance Imaging Techniques in Cancerp490-518ByD. M. Morris;D. M. MorrisThe University of Manchester, Centre for Imaging SciencesStopford Building, Oxford Road, Manchester, M13 9PTUKSearch for other works by this author on:J. P. B. O’Connor;J. P. B. O’ConnorThe University of Manchester, Centre for Imaging SciencesStopford Building, Oxford Road, Manchester, M13 9PTUKSearch for other works by this author on:A. JacksonA. JacksonThe University of Manchester, Wolfson Molecular Imaging Institute27 Palatine Road, Manchester, M20 3LJUK[email protected]Search for other works by this author on:
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