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This chapter particularly emphasises peptide design as a tool providing functional peptide structures for biologically relevant applications, and primarily covers specialist research findings published over the last few years to the time of its submission. A necessary reference to background information covers an unlimited timeframe. Prescriptive or de novo design of polypeptide sequences encoding specific functions found in native systems is of a primary focus.

The chapter reviews literature sourced from different databases including Web of Science, RCSB Protein Data Bank and PubMed. Individual sections are arranged according to targeted functions with structural preferences and definitions consequently referring to design types. A section describing basic design principles provides an introduction to the problem of peptide design and structure-function relationships.

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