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Small interfering RNAs (siRNAs) have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing siRNA delivery vectors thanks to their unique well‐defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present chapter offers a brief overview of the structurally flexible triethanolamine‐core poly(amidoamine) (PAMAM) dendrimers and amphiphilic dendrimers developed in our group as non‐viral vectors for siRNA delivery in the course of this COST action. Their excellent activity for delivering RNA therapeutics in various disease models in vitro and in vivo will be highlighted here.

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