Poly(Aminoester) Dendrimers: Design, Synthesis and Characterization

Poly(aminoester) dendrimers are particularly appealing for drug delivery due to their advantageous properties including biodegradability, potentially lower toxicity and possibility of diverse chemical conjugations. In the course of the COST Action TD0802, we have developed a novel strategy for the synthesis of poly(aminoester) dendrimers based on active cyanomethyl ester intermediates and the iteration of 4 consecutive steps involving deprotection, activation, transesterification and scavenging. The overall synthesis can be performed under very mild conditions, allowing the corresponding products to be obtained in pure form and with good yields after easy purification.