Microfluidics for Medical Applications
Lab-on-a-chip devices for point of care diagnostics have been present in clinics for several years now. Alongside their continual development, research is underway to bring the organs and tissue on-a-chip to the patient, amongst other medical applications of microfluidics.
This book provides the reader with a comprehensive review of the latest developments in the application of microfluidics to medicine and is divided into three main sections. The first part of the book discusses the state-of-the-art in organs and tissue on a chip; the second provides a thorough background to microfluidics for medicine, and the third (and largest) section provides numerous examples of point-of-care diagnostics.
Written with students and practitioners in mind, and with contributions from the leaders in the field across the globe, this book provides a complete digest of the state-of-the-art in microfluidics medical devices and will provide a handy resource for any laboratory or clinic involved in the development or application of such devices.
Royal Society of Chemistry, Microfluidics for Medical Applications, The Royal Society of Chemistry, 2014.
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Table of contents
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Chapter 1: Microtechnologies in the Fabrication of Fibers for Tissue Engineeringp1-18ByMohsen Akbari;Mohsen AkbariBiomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical SchoolCambridgeMA 02139USAHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of TechnologyCambridgeMA 02139USAWyss Institute for Biologically Inspired Engineering, Harvard UniversityCambridgeMA02139USABiomedical Engineering Department, McGill UniversityMontrealH3A 0G1CanadaSearch for other works by this author on:Ali Tamayol;Ali TamayolBiomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical SchoolCambridgeMA 02139USAHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of TechnologyCambridgeMA 02139USAWyss Institute for Biologically Inspired Engineering, Harvard UniversityCambridgeMA02139USABiomedical Engineering Department, McGill UniversityMontrealH3A 0G1CanadaSearch for other works by this author on:Nasim Annabi;Nasim AnnabiBiomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical SchoolCambridgeMA 02139USAHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of TechnologyCambridgeMA 02139USAWyss Institute for Biologically Inspired Engineering, Harvard UniversityCambridgeMA02139USASearch for other works by this author on:David Juncker;David JunckerBiomedical Engineering Department, McGill UniversityMontrealH3A 0G1CanadaSearch for other works by this author on:Ali KhademhosseiniAli KhademhosseiniBiomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical SchoolCambridgeMA 02139USAHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of TechnologyCambridgeMA 02139USAWyss Institute for Biologically Inspired Engineering, Harvard UniversityCambridgeMA02139USASearch for other works by this author on:
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Chapter 2: Kidney on a Chipp19-39ByLaura Ha;Laura HaInterdisciplinary Program of Bioengineering, Seoul National UniversitySeoul,151-742KoreaSearch for other works by this author on:Kyung-Jin Jang;Kyung-Jin JangWyss Institute for Biologically Inspired Engineering at Harvard UniversityBoston,MA 02115USASearch for other works by this author on:Kahp-Yang SuhKahp-Yang SuhInterdisciplinary Program of Bioengineering, Seoul National UniversitySeoul,151-742KoreaSchool of Mechanical and Aerospace Engineering, Seoul National UniversitySeoul,151-742Korea[email protected]Search for other works by this author on:
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Chapter 3: Blood-brain Barrier (BBB): An Overview of the Research of the Blood-brain Barrier Using Microfluidic Devicesp40-56ByAndries D. van der Meer;Andries D. van der MeerWyss Institute for Biologically Inspired Engineering, Harvard UniversityBostonUSASearch for other works by this author on:Floor Wolbers;Floor WolbersEindhoven University of Technology, Microsystems Group, Department of Mechanical Engineering and ICMS Institute for Complex Molecular SystemsThe Netherlands[email protected]Search for other works by this author on:Istvãn Vermes;Istvãn VermesUniversity of Twente, BIOS Lab on a Chip group, MESA+ Institute for NanotechnologyEnschedeThe Netherlands[email protected]Search for other works by this author on:Albert van den BergAlbert van den BergUniversity of Twente, BIOS Lab on a Chip group, MESA+ Institute for NanotechnologyEnschedeThe Netherlands[email protected]Search for other works by this author on:
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Chapter 4: The Use of Microfluidic-based Neuronal Cell Cultures to Study Alzheimer's Diseasep57-80ByRobert Meissner;Robert MeissnerMicrosystems laboratory (LMIS4), Ecole Polytechnique Fédérale de LausanneStation 17, CH-1015LausanneSwitzerland[email protected]Search for other works by this author on:Philippe RenaudPhilippe RenaudMicrosystems laboratory (LMIS4), Ecole Polytechnique Fédérale de LausanneStation 17, CH-1015LausanneSwitzerland[email protected]Search for other works by this author on:
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Chapter 5: Microbubbles for Medical Applicationsp81-101ByTim Segers;Tim SegersPhysics of Fluids Group, MIRA Institute for Biomedical Technology and Technical Medicine, MESA+ Institute for Nanotechnology, University of TwentePO Box 2177500 AE EnschedeThe Netherlands[email protected]Search for other works by this author on:Nico de Jong;Nico de JongPhysics of Fluids Group, MIRA Institute for Biomedical Technology and Technical Medicine, MESA+ Institute for Nanotechnology, University of TwentePO Box 2177500 AE EnschedeThe Netherlands[email protected]Search for other works by this author on:Detlef Lohse;Detlef LohsePhysics of Fluids Group, MIRA Institute for Biomedical Technology and Technical Medicine, MESA+ Institute for Nanotechnology, University of TwentePO Box 2177500 AE EnschedeThe Netherlands[email protected]Search for other works by this author on:Michel VersluisMichel VersluisPhysics of Fluids Group, MIRA Institute for Biomedical Technology and Technical Medicine, MESA+ Institute for Nanotechnology, University of TwentePO Box 2177500 AE EnschedeThe Netherlands[email protected]Search for other works by this author on:
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Chapter 6: Magnetic Particle Actuation in Stationary Microfluidics for Integrated Lab-on-Chip Biosensorsp102-130ByAlexander van Reenen;Alexander van ReenenDepartment of Applied PhysicsEindhoven University of Technology5600 MB EindhovenThe NetherlandsInstitute for Complex Molecular SystemsEindhoven University of Technology5600 MB EindhovenThe NetherlandsSearch for other works by this author on:Arthur M. de Jong;Arthur M. de JongDepartment of Applied PhysicsEindhoven University of Technology5600 MB EindhovenThe NetherlandsInstitute for Complex Molecular SystemsEindhoven University of Technology5600 MB EindhovenThe NetherlandsSearch for other works by this author on:Jaap M. J. den Toonder;Jaap M. J. den ToonderDepartment of Mechanical EngineeringEindhoven University of Technology5600 MB EindhovenThe NetherlandsInstitute for Complex Molecular SystemsEindhoven University of Technology5600 MB EindhovenThe NetherlandsSearch for other works by this author on:Menno W. J. PrinsMenno W. J. PrinsDepartment of Applied PhysicsEindhoven University of Technology5600 MB EindhovenThe NetherlandsInstitute for Complex Molecular SystemsEindhoven University of Technology5600 MB EindhovenThe NetherlandsSearch for other works by this author on:
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Chapter 7: Microfluidics for Assisted Reproductive Technologiesp131-150ByDavid Lai;David LaiBiointerfaces Institute, University of MichiganA183 Bldg. 10 NCRC, 2800 Plymouth RdAnn Arbor, MI48109USA[email protected]Search for other works by this author on:Joyce Han-Ching Chiu;Joyce Han-Ching ChiuBiointerfaces Institute, University of MichiganA183 Bldg. 10 NCRC, 2800 Plymouth RdAnn Arbor, MI48109USA[email protected]Search for other works by this author on:Gary D. Smith;Gary D. SmithBiointerfaces Institute, University of MichiganA183 Bldg. 10 NCRC, 2800 Plymouth RdAnn Arbor, MI48109USA[email protected]Search for other works by this author on:Shuichi TakayamaShuichi TakayamaBiointerfaces Institute, University of MichiganA183 Bldg. 10 NCRC, 2800 Plymouth RdAnn Arbor, MI48109USA[email protected]Search for other works by this author on:
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Chapter 8: Microfluidic Diagnostics for Low-resource Settings: Improving Global Health without a Power Cordp151-190ByJoshua R. Buser;Joshua R. BuserUniversity of Washington, Dept. of BioengineeringBox 355061, 3720 15th Ave. NESeattleWA 98195[email protected]Search for other works by this author on:Carly A. Holstein;Carly A. HolsteinUniversity of Washington, Dept. of BioengineeringBox 355061, 3720 15th Ave. NESeattleWA 98195[email protected]Search for other works by this author on:Paul YagerPaul YagerUniversity of Washington, Dept. of BioengineeringBox 355061, 3720 15th Ave. NESeattleWA 98195[email protected]Search for other works by this author on:
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Chapter 9: Isolation and Characterization of Circulating Tumor Cellsp191-212ByYoonsun Yang;Yoonsun YangMedical Cell BioPhysics Group, MIRA Institute, University of TwenteHallenweg 237522 NHEnschedeThe Netherlands[email protected]Search for other works by this author on:Leon W. M. M. TerstappenLeon W. M. M. TerstappenMedical Cell BioPhysics Group, MIRA Institute, University of TwenteHallenweg 237522 NHEnschedeThe Netherlands[email protected]Search for other works by this author on:
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Chapter 10: Microfluidic Impedance Cytometry for Blood Cell Analysisp213-241ByHywel Morgan;Hywel MorganFaculty of Physical and Applied Sciences, and Institute for Life Sciences, University of SouthamptonUK[email protected]Search for other works by this author on:Daniel SpencerDaniel SpencerFaculty of Physical and Applied Sciences, and Institute for Life Sciences, University of SouthamptonUK[email protected]Search for other works by this author on:
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Chapter 11: Routine Clinical Laboratory Diagnostics Using Point of Care or Lab on a Chip Technologyp242-258ByGábor L. Kovács;Gábor L. KovácsInstitute for Laboratory Medicine, Medical Faculty, University PécsIfjúság u. 137624PécsHungarySzentágothai Research Centre, University PécsIfjúság u. 137624PécsHungarySearch for other works by this author on:István VermesIstván VermesSzentágothai Research Centre, University PécsIfjúság u. 137624PécsHungaryBIOS, Lab in a Chip Group, MESA+ Institute for Nanotechnology, University TwentePO Box 217, 7500 AEEnschedeThe Netherlands[email protected]Search for other works by this author on:
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Chapter 12: Medimate Minilab, a Microchip Capillary Electrophoresis Self-test Platformp259-288BySteven S. Staal;Steven S. StaalMedimate BVDe Veldmaat 107522 NMEnschedethe NetherlandsSearch for other works by this author on:Mathijn C. Ungerer;Mathijn C. UngererMedimate BVDe Veldmaat 107522 NMEnschedethe NetherlandsSearch for other works by this author on:Kris L. L. Movig;Kris L. L. MovigDepartment of Clinical Pharmacy, Medical Spectrum TwenteHaaksbergerstraat 557513 EREnschedethe NetherlandsSearch for other works by this author on:Jody A. Bartholomew;Jody A. BartholomewMedlon BVAriensplein 17500 KAEnschedethe NetherlandsSearch for other works by this author on:Hans Krabbe;Hans KrabbeMedlon BVAriensplein 17500 KAEnschedethe NetherlandsSearch for other works by this author on:Jan C. T. EijkelJan C. T. EijkelBios Lab-on-a-Chip Group, University of TwenteDrienerlolaan 57500 AEEnschedethe Netherlands[email protected]Search for other works by this author on:
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