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In this chapter, a general overview of progress made on the kidney on a chip will be introduced. We will focus on the understanding of kidney structure and function, and application of micro-engineered kidney-mimetic microsystems for the study of kidney function and disease in vitro. We will also discuss the potential use of these “kidney chips” for biomedical pharmaceutical and environmental safety testing applications as well as challenges for the field that must be overcome to translate these technologies into useful products in the future.

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