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Drug Discovery
Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics
Edited by
Glenn F. King
Glenn F. King
The University of Queensland, Australia
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Hardback ISBN:
978-1-84973-663-3
PDF ISBN:
978-1-84973-787-6
EPUB ISBN:
978-1-78262-437-0
Series:
Drug Discovery
No. of Pages:
320
Published online:
27 Jan 2015
Published in print:
10 Feb 2015
About this book
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.
Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics, The Royal Society of Chemistry, 2015.
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Digital access
$237.00
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Venoms to Drugs
$237.00
Table of contents
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Seeing the Woods for the Trees: Understanding Venom Evolution as a Guide for Biodiscoveryp1-36ByBryan G. Fry;Bryan G. FryVenom Evolution Lab, School of Biological Sciences, The University of QueenslandSt. LuciaQueensland 4072Australia[email protected]Institute for Molecular Bioscience, The University of QueenslandSt. LuciaQueensland 4072AustraliaSearch for other works by this author on:Ivan Koludarov;Ivan KoludarovVenom Evolution Lab, School of Biological Sciences, The University of QueenslandSt. LuciaQueensland 4072Australia[email protected]Search for other works by this author on:Timothy N. W. Jackson;Timothy N. W. JacksonVenom Evolution Lab, School of Biological Sciences, The University of QueenslandSt. LuciaQueensland 4072Australia[email protected]Institute for Molecular Bioscience, The University of QueenslandSt. LuciaQueensland 4072AustraliaSearch for other works by this author on:Mandë Holford;Mandë HolfordThe City University of New York-Hunter College & CUNY Graduate Center and The American Museum of Natural HistoryNew YorkNew YorkUSASearch for other works by this author on:Yves Terrat;Yves TerratMontréal University, Research Institute in Plant BiologyMontreal Botanical GardenMontrealQuébecCanadaSearch for other works by this author on:Nicholas R. Casewell;Nicholas R. CasewellAlistair Reid Venom Research Unit, Liverpool School of Tropical MedicineLiverpool L3 5QAUKSearch for other works by this author on:Eivind A. B. Undheim;Eivind A. B. UndheimVenom Evolution Lab, School of Biological Sciences, The University of QueenslandSt. LuciaQueensland 4072Australia[email protected]Institute for Molecular Bioscience, The University of QueenslandSt. LuciaQueensland 4072AustraliaSearch for other works by this author on:Irina Vetter;Irina VetterInstitute for Molecular Bioscience, The University of QueenslandSt. LuciaQueensland 4072AustraliaSearch for other works by this author on:Syed A. Ali;Syed A. AliVenom Evolution Lab, School of Biological Sciences, The University of QueenslandSt. LuciaQueensland 4072Australia[email protected]Institute for Molecular Bioscience, The University of QueenslandSt. LuciaQueensland 4072AustraliaHEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of KarachiKarachi 75270PakistanSearch for other works by this author on:Dolyce H. W. Low;Dolyce H. W. LowVenom Evolution Lab, School of Biological Sciences, The University of QueenslandSt. LuciaQueensland 4072Australia[email protected]Search for other works by this author on:Kartik SunagarKartik SunagarCIMAR/CIIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do PortoRua dos Bragas, 1774050-123 PortoPortugalDepartamento de Biologia, Faculdade de Ciências, Universidade do PortoRua do Campo Alegre4169-007 PortoPortugalSearch for other works by this author on:
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CHAPTER 2: The Structural Universe of Disulfide-Rich Venom Peptidesp37-79ByVincent Lavergne;Vincent LavergneInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQLD 4072Australia[email protected][email protected]Search for other works by this author on:Paul F. Alewood;Paul F. AlewoodInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQLD 4072Australia[email protected][email protected]Search for other works by this author on:Mehdi Mobli;Mehdi MobliInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQLD 4072Australia[email protected][email protected]Search for other works by this author on:Glenn F. KingGlenn F. KingInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQLD 4072Australia[email protected][email protected]Search for other works by this author on:
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CHAPTER 3: Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approachesp80-96BySébastien Dutertre;Sébastien DutertreInstitut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier 2 - CNRSPlace Eugène Bataillon34095 Montpellier Cedex 5France[email protected]Search for other works by this author on:Eivind A. B. Undheim;Eivind A. B. UndheimInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaCentre for Advanced Imaging, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Sandy S. Pineda;Sandy S. PinedaInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Ai-Hua Jin;Ai-Hua JinInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Vincent Lavergne;Vincent LavergneInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Bryan G. Fry;Bryan G. FryInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Richard J. Lewis;Richard J. LewisInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Paul F. Alewood;Paul F. AlewoodInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:Glenn F. KingGlenn F. KingInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072AustraliaSearch for other works by this author on:
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CHAPTER 4: Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identificationp97-128ByIrina Vetter;Irina VetterSchool of Pharmacy, The University of QueenslandSt Lucia 4072AustraliaInstitute for Molecular Bioscience, The University of QueenslandSt Lucia 4072AustraliaSearch for other works by this author on:Wayne C. Hodgson;Wayne C. HodgsonDepartment of Pharmacology, Monash UniversityClayton3168AustraliaSearch for other works by this author on:David J. Adams;David J. AdamsHealth Innovations Research Institute and School of Medical Sciences, RMIT UniversityBundoora3083Australia[email protected]Search for other works by this author on:Peter McIntyrePeter McIntyreHealth Innovations Research Institute and School of Medical Sciences, RMIT UniversityBundoora3083Australia[email protected]Search for other works by this author on:
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CHAPTER 5: Reptile Venoms as a Platform for Drug Developmentp129-162ByRyan J. R. McCleary;Ryan J. R. McClearyNational University of Singapore, Department of Biological Sciences14 Science Drive 4Singapore 117543SingaporeSearch for other works by this author on:Tse S. Kang;Tse S. KangNational University of Singapore, Department of Pharmacy18 Science Drive 4Singapore 117543SingaporeSearch for other works by this author on:R. Manjunatha KiniR. Manjunatha KiniNational University of Singapore, Department of Biological Sciences14 Science Drive 4Singapore 117543SingaporeVirginia Commonwealth University, Department of Biochemistry – Medical College of VirginiaRichmondVirginia 23298-0614USAUniversity of South Australia, School of Pharmacy and Medical SciencesAdelaideSouth Australia 5001Australia[email protected]Search for other works by this author on:
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CHAPTER 6: The Molecular Diversity of Conoidean Venom Peptides and their Targets: From Basic Research to Therapeutic Applicationsp163-203ByGrzegorz Bulaj;Grzegorz BulajUniversity of Utah, Department of Medicinal ChemistrySalt Lake CityUtah 84112USASearch for other works by this author on:Martin P. HorvathMartin P. HorvathSearch for other works by this author on:
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CHAPTER 7: Scorpion Venoms as a Platform for Drug Developmentp204-220ByRicardo C. Rodríguez de la Vega;Ricardo C. Rodríguez de la VegaEcologie, Systématique et Evolution, UMR 8079, Université Paris-SudF-91405 Orsay CedexFrance[email protected]UMR 8079, CNRSF-91405 Orsay CedexFranceSearch for other works by this author on:Gerardo Corzo;Gerardo CorzoDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad2001 Cuernavaca, Mor. 62210MéxicoSearch for other works by this author on:Lourival D. PossaniLourival D. PossaniDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad2001 Cuernavaca, Mor. 62210MéxicoSearch for other works by this author on:
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Chapter 8: Therapeutic Applications of Spider-Venom Peptidesp221-244ByJennifer J. Smith;Jennifer J. SmithInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072Australia[email protected][email protected]Search for other works by this author on:Carus Ho Yee Lau;Carus Ho Yee LauInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072Australia[email protected][email protected]Search for other works by this author on:Volker Herzig;Volker HerzigInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072Australia[email protected][email protected]Search for other works by this author on:Maria P. Ikonomopoulou;Maria P. IkonomopoulouInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072Australia[email protected][email protected]Search for other works by this author on:Lachlan D. Rash;Lachlan D. RashInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072Australia[email protected][email protected]Search for other works by this author on:Glenn F. KingGlenn F. KingInstitute for Molecular Bioscience, The University of QueenslandSt LuciaQueensland 4072Australia[email protected][email protected]Search for other works by this author on:
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CHAPTER 9: Case Study 1: Development of the Analgesic Drugs Prialt® and Xen2174 from Cone Snail Venomsp245-254ByRichard J. LewisRichard J. LewisCentre for Pain Research, Institute for Molecular Bioscience, The University of QueenslandSt Lucia QLD 4072Australia[email protected]Search for other works by this author on:
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CHAPTER 10: Case Study 2: Transforming a Toxin into a Therapeutic: the Sea Anemone Potassium Channel Blocker ShK Toxin for Treatment of Autoimmune Diseasesp255-274ByRaymond S. Norton;Raymond S. NortonMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash UniversityParkvilleVictoria 3052Australia[email protected]Search for other works by this author on:Michael W. Pennington;Michael W. PenningtonPeptides International11621 Electron DriveLouisvilleKY 40299USASearch for other works by this author on:Christine BeetonChristine BeetonDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineHoustonTX 77030USASearch for other works by this author on:
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CHAPTER 11: Engineering Venom Peptides to Improve Their Stability and Bioavailabilityp275-289ByMuharrem Akcan;Muharrem AkcanInstitute for Molecular Bioscience, The University of QueenslandBrisbaneQLD 4072Australia[email protected]Search for other works by this author on:David J. CraikDavid J. CraikInstitute for Molecular Bioscience, The University of QueenslandBrisbaneQLD 4072Australia[email protected]Search for other works by this author on:
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CHAPTER 12: Manufacturing of Venom-Derived Therapeutic Peptidesp290-305ByMatthieu GiraudMatthieu GiraudBASF Pharma SAroute du Simplon 1,36CH-1902 EvionnazSwitzerlandSearch for other works by this author on:
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