CHAPTER 3: Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches

Modern proteomic and transcriptomic approaches have revolutionised our understanding of the chemical diversity of animal venoms. Moreover, recent studies have highlighted the value of combining these approaches (for example, by combining mass spectrometry derived sequence tags with deep sequencing information). These approaches are allowing more rapid deconvolution of hit venoms, as well as identification of orthologues/paralogues of lead molecules with potentially useful variations in activity. The aim of this chapter is to demonstrate the impact of modern proteomic and transcriptomic approaches on venoms-based drug discovery and to discuss their likely impact in future years.