CHAPTER 13: Constitutional Dynamic Chemistry for Bioactive Compounds

In this chapter, the concept of dynamic chemistry at the constitutional level is described, and recent applications illustrated. The concept efficiently enables the in situ selection of optimal bioactive compounds for various external targets, providing information of the biological entities together with the substrates. It has been much explored and expanded during the last decade, where reversible reactions constitute the key step in establishing complex dynamic systems. In combination with different biological targets, optimal ligands and inhibitors have been selected and amplified and, in some cases, potential drug leads have been identified and further designed from the dynamic systems.