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This chapter provides a materials perspective to recent developments in biomimetic underwater adhesives for functionalizing a wide range of surfaces. The first part of the chapter is devoted to providing an overview towards mussel adhesion as the source of inspiration. The focus is then shifted to review fully synthetic mussel‐mimetic systems developed for a variety of surface applications. In the last part of the chapter, we concentrate on a mussel‐mimetic, hybrid supramolecular adhesive system for biofunctionalization of metal implant surfaces. By making an analogy between the challenging environmental conditions of the intertidal zones and body environment, we propose that the adhesive strategies of marine organisms are suitable models for developing advanced biomedical and tissue adhesives.

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