Skip Nav Destination
Drug Discovery
Inhibitors of Molecular Chaperones as Therapeutic Agents
Edited by
Timothy D Machajewski;
Timothy D Machajewski
Achaogen Inc, USA
Search for other works by this author on:
Hardback ISBN:
978-1-84973-666-4
PDF ISBN:
978-1-84973-968-9
Series:
Drug Discovery
No. of Pages:
442
Publication date:
23 Oct 2013
About this book
This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.
Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.
Inhibitors of Molecular Chaperones as Therapeutic Agents, The Royal Society of Chemistry, 2013.
Download citation file:
Digital access
$224.00
Print format
Inhibitors of Molecular Chaperones as Therapeutic Agents
$224.00
Table of contents
-
CHAPTER 1: Overview of Molecular Chaperones in Health and Diseasep1-36ByTai Wang;Tai WangDépartement de Biologie CellulaireUniversité de Genève, Sciences III, 30 Quai Ernest-Ansermet, 1211 Genève 4Switzerland[email protected]Search for other works by this author on:Pablo C. Echeverría;Pablo C. EcheverríaDépartement de Biologie CellulaireUniversité de Genève, Sciences III, 30 Quai Ernest-Ansermet, 1211 Genève 4Switzerland[email protected]Search for other works by this author on:Didier PicardDidier PicardDépartement de Biologie CellulaireUniversité de Genève, Sciences III, 30 Quai Ernest-Ansermet, 1211 Genève 4Switzerland[email protected]Search for other works by this author on:
-
CHAPTER 2: Structural Basis of Hsp90 Functionp37-64ByChrisostomos Prodromou;Chrisostomos ProdromouGenome Damage and Stability CentreSchool of Life Sciences, Science Park Road, Falmer, Brighton, East Sussex BN1 9RQUK[email protected]Search for other works by this author on:Laurence H. PearlLaurence H. PearlGenome Damage and Stability CentreSchool of Life Sciences, Science Park Road, Falmer, Brighton, East Sussex BN1 9RQUK[email protected]Search for other works by this author on:
-
CHAPTER 3: Structure and Function of Hsp70 Molecular Chaperonesp65-125ByEugenia M. Clerico;Eugenia M. ClericoDepartment of Biochemistry and Molecular BiologyUniversity of Massachusetts, Amherst, MA 01003USASearch for other works by this author on:Lila M. GieraschLila M. GieraschDepartment of Biochemistry and Molecular BiologyUniversity of Massachusetts, Amherst, MA 01003USADepartment of ChemistryUniversity of Massachusetts, Amherst, MA 01003USA[email protected][email protected]Search for other works by this author on:
-
CHAPTER 4: Exploiting the Dependency of Cancer Cells on Molecular Chaperonesp126-157BySwee Sharp;Swee SharpCancer Research UK Cancer Therapeutics UnitDivision of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NGUK[email protected]Search for other works by this author on:Jenny Howes;Jenny HowesCancer Research UK Cancer Therapeutics UnitDivision of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NGUK[email protected]Search for other works by this author on:Paul WorkmanPaul WorkmanCancer Research UK Cancer Therapeutics UnitDivision of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NGUK[email protected]Search for other works by this author on:
-
CHAPTER 5: The Discovery of BIIB021 and BIIB028p158-179ByKaren Lundgren;Karen LundgrenK Lundgren Pharmacology1804 Garnet Ave, Unit 246, San Diego, CA 92109USASearch for other works by this author on:Marco A. BiamonteMarco A. BiamonteDrug Discovery for Tropical Diseases10835 Road to the Cure, Suite 230, San Diego, CA 92121USA[email protected]Search for other works by this author on:
-
CHAPTER 6: Discovery and Development of Ganetespibp180-197ByWeiwen YingWeiwen YingSearch for other works by this author on:
-
CHAPTER 7: Discovery of the Serenex Hsp90 Inhibitor, SNX5422p198-212ByTimothy Haystead;Timothy HaysteadDepartment of Pharmacology and Cancer BiologyDuke University Medical Center, Durham, NC 27710USA[email protected]Search for other works by this author on:Philip HughesPhilip HughesDepartment of Pharmacology and Cancer BiologyDuke University Medical Center, Durham, NC 27710USA[email protected]Search for other works by this author on:
-
CHAPTER 8: Discovery of NVP-AUY922p213-240ByPaul A. Brough;Paul A. BroughVernalis Ltd, Granta Park, Great AbingtonCambridge, CB21 6GBUKSearch for other works by this author on:Andrew Massey;Andrew MasseyVernalis Ltd, Granta Park, Great AbingtonCambridge, CB21 6GBUKSearch for other works by this author on:Michael Rugaard JensenMichael Rugaard JensenSearch for other works by this author on:
-
CHAPTER 9: Discovery and Selection of NVP-HSP990 as a Clinical Candidatep241-258ByTimothy D. Machajewski;Timothy D. MachajewskiNovartis Institutes for BioMedical Research4560 Horton Street Emeryville, CA 94608USA[email protected]Search for other works by this author on:Daniel Menezes;Daniel MenezesNovartis Institutes for BioMedical Research4560 Horton Street Emeryville, CA 94608USA[email protected]Search for other works by this author on:Zhenhai GaoZhenhai GaoNovartis Institutes for BioMedical Research4560 Horton Street Emeryville, CA 94608USA[email protected]Search for other works by this author on:
-
CHAPTER 10: Inhibitors of the Hsp90 C-terminusp259-301ByHuiping Zhao;Huiping ZhaoDepartment of Medicinal Chemistry, 1251 Wescoe Hall Drive, Malott 4070The University of Kansas, Lawrence, Kansas 66045-7563USA[email protected]Search for other works by this author on:Brian S. J. BlaggBrian S. J. BlaggDepartment of Medicinal Chemistry, 1251 Wescoe Hall Drive, Malott 4070The University of Kansas, Lawrence, Kansas 66045-7563USA[email protected]Search for other works by this author on:
-
CHAPTER 11: Hsp70 Inhibitorsp302-317ByYaoyu Chen;Yaoyu ChenOncologyNovartis Institutes for Biomedical Research, Cambridge, MAUSA[email protected][email protected]Search for other works by this author on:Wenlai ZhouWenlai ZhouOncologyNovartis Institutes for Biomedical Research, Cambridge, MAUSA[email protected][email protected]Search for other works by this author on:
-
CHAPTER 12: The Cancer Super-chaperone Hsp90: Drug Targeting and Post-translational Regulationp318-335ByAnnerleim Walton-Diaz;Annerleim Walton-DiazUrologic Oncology Branch and Medical Oncology BranchCenter for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-1107USA[email protected]Search for other works by this author on:Sahar Khan;Sahar KhanUrologic Oncology Branch and Medical Oncology BranchCenter for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-1107USA[email protected]Search for other works by this author on:Jane B. Trepel;Jane B. TrepelUrologic Oncology Branch and Medical Oncology BranchCenter for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-1107USA[email protected]Search for other works by this author on:Mehdi Mollapour;Mehdi MollapourUrologic Oncology Branch and Medical Oncology BranchCenter for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-1107USA[email protected]Search for other works by this author on:Len NeckersLen NeckersUrologic Oncology Branch and Medical Oncology BranchCenter for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-1107USA[email protected]Search for other works by this author on:
-
CHAPTER 13: Hsp90 Inhibitors in Clinicp336-378ByEmin AvsarEmin AvsarNovartis PharmaceuticalsOncology Translational Medicine, 1 Health Plaza, New JerseyUSA[email protected]Search for other works by this author on:
-
CHAPTER 14: Heat-shock Protein 90 as an Antimalarial Targetp379-391ByUtpal TatuUtpal TatuSearch for other works by this author on:
-
CHAPTER 15: Molecular Chaperones as Potential Therapeutic Targets for Neurological Disordersp392-413ByMarion Delenclos;Marion DelenclosDepartment of NeuroscienceMayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224USA[email protected]Search for other works by this author on:Pamela J. McLeanPamela J. McLeanDepartment of NeuroscienceMayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224USA[email protected]Search for other works by this author on:
Spotlight
Advertisement
Advertisement
