CHAPTER 14: Development of Processes for the Production of Bulk Chemicals by Fermentation at Industrial Scale – An Integrated Approach
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Published:30 Nov 2015
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Series: Green Chemistry Series
J. Magnus, in White Biotechnology for Sustainable Chemistry, ed. M. A. Coelho and B. D. Ribeiro, The Royal Society of Chemistry, 2015, pp. 362-390.
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A large number of bulk chemicals that are currently produced by petrochemical processes can potentially be produced from renewable resources by fermentation. The diversity of enzymes in nature allows the construction of biosynthesis pathways for a number of common industrial chemicals. The challenges are the cost competition with the petrochemical process and the technical feasibility, as well as the time and budget needed to develop the bioprocess. This chapter discusses the setup of projects for efficient and targeted development of bioprocesses in alignment with the business drivers of the producing company. The most important methods in strain development and process development are reviewed and an industrial view on bioprocess development is given. The benefits of integrating strain development with process development, and of performing these in parallel are emphasized.