CHAPTER 9: Lipases in Enantioselective Syntheses: Evolution of Technology and Recent Applications
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Published:30 Nov 2015
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Series: Green Chemistry Series
D. M. Guimarães Freire, A. A. Theodoro da Silva, E. de Andrade Manoel, R. V. Almeida, and A. B. Costa Simas, in White Biotechnology for Sustainable Chemistry, ed. M. A. Coelho and B. D. Ribeiro, The Royal Society of Chemistry, 2015, pp. 207-244.
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Lipases are the most widely employed biocatalysts in enantioselective syntheses. In this review, we discuss, with a historical perspective, the advances in the technology behind lipase catalysis. The different classes (resolutions, deracemizations, desymmetrizations) of lipase-catalysed processes towards enantioselective synthesis are briefly discussed. The relevance of such biocatalysts and the practicality of their use in this context are discussed with regards to features such as medium engineering, immobilization, protein engineering, reactor technology and new media (e.g., ionic liquids), whose advances we discuss herein.