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Protein adsorption on solid material surfaces is a widespread, common phenomenon, playing a fundamental role in many natural and biological processes. It has therefore attracted broad interest throughout many disciplines, including medicine, biology, pharmaceutical and food science, and has been the subject of numerous experimental, theoretical and computational investigations.

Protein adsorption on engineered nano- and colloidal particles is known to strongly determine particle biological fate and functionality, such as particle agglomeration, biodistribution, trafficking, cellular uptake and their overall cytotoxicity level.1–3 

On artificial tissues and engineered scaffolds, protein adsorption has an important effect and is determinant for their integration, biocompatibility and functionality.4  The adsorption of serum proteins can lead to fouling processes, blood clot formation (thrombosis) and immunoreactions; it influences the adhesion of blood cells and macrophages or platelets, thereby guiding inflammation and vascularization processes.5,6 

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