Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials
The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research.
Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles.
The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials, The Royal Society of Chemistry, 2015.
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Table of contents
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CHAPTER 1: Matrix Biology: Extracellular Matrix – Building Function Through Complexityp3-30ByLinda J. SandellLinda J. SandellDepartment of Orthopaedic Surgery, Department of Cell Biology and Physiology, Department of Biomedical Engineering, Washington University Medical School660 S. Euclid Ave, CB 8233St. LouisMO 63110USA[email protected]Search for other works by this author on:
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CHAPTER 2: Matrix Biology: Gradients and Patterns within the Extracellular Matrixp31-64ByMauricio Cortes;Mauricio CortesDepartments of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolBostonMA 02115USASearch for other works by this author on:Nancy B. SchwartzNancy B. SchwartzDepartments of Pediatrics and Biochemistry & Molecular Biology, Committee on Developmental Biology, The University of ChicagoChicagoIL 60637USASearch for other works by this author on:
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CHAPTER 3: Matrix Biology: ECM Turnover and Temporal Fluctuationp65-102ByQuyen Tran;Quyen TranDepartment of Biomedical Engineering, University of Wisconsin-MadisonMadisonWI 53706USASearch for other works by this author on:Brenda M. OgleBrenda M. OgleDepartment of Biomedical Engineering, University of Wisconsin-MadisonMadisonWI 53706USADepartment of Biomedical Engineering, University of Minnesota-Twin CitiesMinneapolisMN 55455USA[email protected]Search for other works by this author on:
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CHAPTER 4: Matrix Biology: Structure and Assembly of Laminin-Rich Matricesp103-158ByKevin J. Hamill;Kevin J. HamillDepartment of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of LiverpoolLiverpoolUKSearch for other works by this author on:Natalie M. E. Hill;Natalie M. E. HillDepartment of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of LiverpoolLiverpoolUKSearch for other works by this author on:Jonathan C. R. JonesJonathan C. R. JonesSearch for other works by this author on:
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CHAPTER 5: Biomaterials: Incorporating ECM-Derived Molecular Features into Biomaterialsp161-194ByKristopher A. KilianKristopher A. KilianDepartment of Materials Science and Engineering, University of Illinois at Urbana Champaign1304 West Green StUrbanaIL 61801USA[email protected]Search for other works by this author on:
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CHAPTER 6: Biomaterials: Modulating and Tuning Synthetic Extracellular Matrix Mechanicsp195-216ByElizabeth Jin;Elizabeth JinDepartment of Orthopedics and Rehabilitation, Department of Biomedical Engineering, University of Wisconsin-MadisonMadisonWI 53705USA[email protected][email protected]Search for other works by this author on:Wan-Ju LiWan-Ju LiDepartment of Orthopedics and Rehabilitation, Department of Biomedical Engineering, University of Wisconsin-MadisonMadisonWI 53705USA[email protected][email protected]Search for other works by this author on:
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CHAPTER 7: Biomaterials: Protein Interactions with Glycosaminoglycan-Based Biomaterials for Tissue Engineeringp219-259ByMelissa C. Goude;Melissa C. GoudeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University313 Ferst DriveAtlantaGeorgia 30332USA[email protected]Search for other works by this author on:Tobias Miller;Tobias MillerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University313 Ferst DriveAtlantaGeorgia 30332USA[email protected]Search for other works by this author on:Todd C. McDevitt;Todd C. McDevittWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University313 Ferst DriveAtlantaGeorgia 30332USA[email protected]Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyAtlantaGeorgia 30332USASearch for other works by this author on:Johnna S. TemenoffJohnna S. TemenoffWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University313 Ferst DriveAtlantaGeorgia 30332USA[email protected]Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyAtlantaGeorgia 30332USASearch for other works by this author on:
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CHAPTER 8: Biomaterials: Spatial Patterning of Biomolecule Presentation Using Biomaterial Culture Methodsp260-282ByKyle A. Kyburz;Kyle A. KyburzDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of ColoradoBoulderUSA[email protected]Search for other works by this author on:Navakanth R. Gandavarapu;Navakanth R. GandavarapuDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of ColoradoBoulderUSA[email protected]Search for other works by this author on:Malar A. Azagarsamy;Malar A. AzagarsamyDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of ColoradoBoulderUSA[email protected]Howard Hughes Medical Institute, University of ColoradoBoulderUSASearch for other works by this author on:Kristi S. AnsethKristi S. AnsethDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of ColoradoBoulderUSA[email protected]Howard Hughes Medical Institute, University of ColoradoBoulderUSASearch for other works by this author on:
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CHAPTER 9: Biomaterials: Controlling Properties Over Time to Mimic the Dynamic Extracellular Matrixp285-334ByApril KloxinApril KloxinSearch for other works by this author on:
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CHAPTER 10: Biomaterials: Supramolecular Artificial Extracellular Matricesp335-389ByGregory A. Hudalla;Gregory A. HudallaJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida1275 Center DriveGainesvilleFL 32611USA[email protected]Search for other works by this author on:Joel H. CollierJoel H. CollierSearch for other works by this author on:
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