Skip to Main Content
Skip Nav Destination

Betaine is a naturally occurring zwitterionic compound at neutral pH possessing quaternary ammonium and carboxylate groups. Hydrophilic interaction liquid chromatography (HILIC) has been developed as a powerful alternative to conventional liquid chromatographic (LC) techniques for the analysis of highly polar and hydrophilic compounds. HILIC is therefore an appropriate technique for the measurement of betaine in a wide variety of sample matrices. In this chapter, the separation principles and types of mobile and stationary phases employed in HILIC are discussed. These are followed by a comparison of analytical methods employing HILIC for betaine analysis with other methods such as normal phase chromatography. Finally, an overview of published results on the determination of betaine in various matrices by HILIC is presented.

You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal