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This chapter highlights developments in peptide design over the last years to the time of its submission, with background information covering an unlimited timeframe. An emphasis is made on prescriptive or de novo design of polypeptide sequences in relation to specific folds, topologies and functions, as seen in native systems. Therefore, the choice of reviewed designs in this chapter is biased towards biologically relevant structures that span molecular and nano- to micrometer length scales, and towards native strategies for their construction, that is self-assembly. The chapter reviews literature sourced from different databases including Web of Science and PubMed. Individual sections are arranged according to structural preferences and definitions and consequently to the types of relevant de novo designs. A section describing basic design principles provides introduction to the problem of peptide design and structure-function relationships.

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