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RSC Chromatography Monographs
Protein and Peptide Analysis by LC-MS: Experimental Strategies
Edited by
Thomas Letzel
Thomas Letzel
Technische Universität München, Germany
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Hardback ISBN:
978-1-84973-182-9
PDF ISBN:
978-1-84973-314-4
Special Collection:
2011 ebook collection
,
2011 ebook collection
,
2011-2015 analytical chemistry subject collection
No. of Pages:
194
Publication date:
22 Jul 2011
Book Chapter
Chapter 4: Liquid Chromatography-Mass Spectrometry of Intact Proteins
By
Nicolas L. Young
;
Nicolas L. Young
Princeton University
Department of Molecular Biology, Princeton
NJ 08544
USA
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Benjamin A. Garcia
Benjamin A. Garcia
Princeton University
Department of Molecular Biology, Princeton
NJ 08544
USA
Princeton University
Department of Chemistry, Princeton
NJ 08544
USA
Search for other works by this author on:
-
Published:22 Jul 2011
-
Special Collection: 2011 ebook collection , 2011 ebook collection , 2011-2015 analytical chemistry subject collection
Page range:
38 - 55
Citation
N. L. Young and B. A. Garcia, in Protein and Peptide Analysis by LC-MS: Experimental Strategies, ed. T. Letzel, The Royal Society of Chemistry, 2011, ch. 4, pp. 38-55.
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In this chapter we address the use of liquid chromatography-mass spectrometry in the analysis of intact proteins. We cover multiple approaches and applications including quantitation, identification and the derivation of structural information. Because of the difficulty of intact protein analysis and the variety of approaches necessary for proteins of different character, we set out a series of principles and provide extensive practical advice on method development, while also introducing a wide range of specific techniques and applications.
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