Animal Models for Neurodegenerative Disease
In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders such as Alzheimer's and Huntington's disease. By reproducing some of the pathological aspects of the diseases, these studies could reveal the mechanism for their onset or development. Some of the transgenic mice can also be used as targets for testing new compounds with the potential to prevent or combat these disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics. The chapters cover disorders including: Alzheimer's disease, Parkinson's disease, Huntington's and other CAG diseases, amyotrophic lateral sclerosis (ALS), recessive ataxias, disease caused by prions, and ischemia.
Animal Models for Neurodegenerative Disease, The Royal Society of Chemistry, 2011.
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The Contribution of Transgenic Models to the Understanding of Alzheimer's Disease Progression and Therapeutic Developmentp1-14ByMeredith A. Chabrier;Meredith A. ChabrierDepartment of Neurobiology and Behavior, Institute of Memory Impairments and Neurological Disorders, University of California IrvineIrvine, CAUSASearch for other works by this author on:Kara M. Neely;Kara M. NeelyDepartment of Neurobiology and Behavior, Institute of Memory Impairments and Neurological Disorders, University of California IrvineIrvine, CAUSASearch for other works by this author on:Nicholas A. Castello;Nicholas A. CastelloDepartment of Neurobiology and Behavior, Institute of Memory Impairments and Neurological Disorders, University of California IrvineIrvine, CAUSASearch for other works by this author on:Frank M. LaFerlaFrank M. LaFerlaDepartment of Neurobiology and Behavior, Institute of Memory Impairments and Neurological Disorders, University of California IrvineIrvine, CAUSASearch for other works by this author on:
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Chapter 2: Animal Models of Amyloid/PS-1 Pathologyp15-38ByAkihiko TakashimaAkihiko TakashimaLaboratory for Alzheimer's DiseaseBrain Science Institute, RIKENSaitamaJapanSearch for other works by this author on:
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Chapter 3: The Ying and Yang of the Reelin Signalling Pathway in Alzheimer's Disease Pathologyp39-51ByEduardo Soriano;Eduardo SorianoDevelopment of Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona; Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED-ISCIII)08028 BarcelonaSpainSearch for other works by this author on:Daniela Rossi;Daniela RossiDevelopment of Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona; Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED-ISCIII)08028 BarcelonaSpainSearch for other works by this author on:Lluís PujadasLluís PujadasDevelopment of Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona; Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED-ISCIII)08028 BarcelonaSpainSearch for other works by this author on:
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Chapter 4: Transgenic Mice Overexpressing GSK-3β as Animal Models for Alzheimer's Diseasep52-68ByFélix HernándezFélix HernándezCentro de Biología Molecular ‘Severo Ochoa’ (CBMSO), Universidad Autónoma de MadridMadridSpainSearch for other works by this author on:
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Chapter 5: Invertebrate and Vertebrate Models of Tauopathiesp69-85ByJürgen Götz;Jürgen GötzAlzheimer's & Parkinson's Disease LaboratoryBrain&Mind Research Institute, University of SydneyAustraliaSearch for other works by this author on:Lars M. Ittner;Lars M. IttnerAlzheimer's & Parkinson's Disease LaboratoryBrain&Mind Research Institute, University of SydneyAustraliaSearch for other works by this author on:Naeman N. Götz;Naeman N. GötzAlzheimer's & Parkinson's Disease LaboratoryBrain&Mind Research Institute, University of SydneyAustraliaSearch for other works by this author on:Hong Lam;Hong LamSchool of Molecular Bioscience, University of SydneyAustraliaSearch for other works by this author on:Hannah R. NicholasHannah R. NicholasSchool of Molecular Bioscience, University of SydneyAustraliaSearch for other works by this author on:
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Chapter 6: Animal Models of Parkinson's Diseasep86-112ByHardy J. Rideout;Hardy J. RideoutDepartment of NeurologyColumbia UniversityNew YorkUSASearch for other works by this author on:Leonidas StefanisLeonidas StefanisDepartment of NeurologyColumbia UniversityNew YorkUSADivision of Basic NeurosciencesBiomedical Research Foundation of the Academy of AthensAthensGreeceSearch for other works by this author on:
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Chapter 7: Animal Models and the Pathogenesis of Parkinson's Diseasep113-161ByJosé G. Castaño;José G. CastañoDepartamento de BioquímicaInstituto de Investigaciones Biomédicas‘Alberto Sols’ (UAM-CSIC), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) and Hospital La Paz Health Research Institute (IdiPaz), Facultad de Medicina UAMMadridSpainSearch for other works by this author on:Teresa Iglesias;Teresa IglesiasInstituto de Investigaciones Biomédicas ‘Alberto Sols’ (CSIC-UAM) and CIBERNEDMadridSpainSearch for other works by this author on:Justo G. de YébenesJusto G. de YébenesDepartamento de Neurologia. Hospital Ramón y Cajal and CIBERNEDMadridSpainSearch for other works by this author on:
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Chapter 8: Neuroprotection in Parkinson's Diseasep162-176ByAlberto Pascual;Alberto PascualCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:Javier Villadiego;Javier VilladiegoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:María Hidalgo-Figueroa;María Hidalgo-FigueroaCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:Simón Méndez-Ferrer;Simón Méndez-FerrerCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:Raquel Gómez-Díaz;Raquel Gómez-DíazCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:Juan José Toledo-Aral;Juan José Toledo-AralCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:José Lopez-BarneoJosé Lopez-BarneoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de SevillaSevillaSpainSearch for other works by this author on:
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Chapter 9: Animal Models for ALSp177-213ByRitsuko Fujii;Ritsuko FujiiLaboratory of Integrative BioscienceGraduate School of Biomedical Sciences, Hiroshima UniversityJapanLaboratory for Anatomy and PhysiologyFaculty of Human Science, Hiroshima Bunkyo Woman's UniversityJapanSearch for other works by this author on:Toru TakumiToru TakumiLaboratory of Integrative BioscienceGraduate School of Biomedical Sciences, Hiroshima UniversityJapanJapan Science and Technology Agent (JST)Core Research for Evolutional Science and Technology (CREST)JapanSearch for other works by this author on:
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Chapter 10: Animal Models for Huntington's Diseasep214-229ByJosé J. LucasJosé J. LucasCentro de Biología Molecular ‘Severo Ochoa’ (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autonoma de Madrid and CiberNedMadridSpainSearch for other works by this author on:
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Chapter 11: Mouse Models of Prion Protein Related Diseasesp230-250ByMaría Gasset;María GassetInsto Química-Física Rocasolano, Consejo Superior de Investigaciones CientíficasMadridSpainSearch for other works by this author on:Adriano AguzziAdriano AguzziInstitute of Neuropathology, University Hospital of ZürichZürichSwitzerlandSearch for other works by this author on:
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Chapter 12: Mouse Models of Ischemiap251-273ByDavid C. Henshall;David C. HenshallDepartment of Physiology and Medical Physics, Royal College of Surgeons in IrelandDublinIrelandSearch for other works by this author on:Roger P. SimonRoger P. SimonMorehouse School of MedicineAtlanta, GAUSASearch for other works by this author on:
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Chapter 13: A Non-transgenic Rat Model of Sporadic Alzheimer's Diseasep274-283ByKhalid Iqbal;Khalid IqbalNew York State Institute for Basic Research in Developmental DisabilitiesStaten Island, New YorkUSASearch for other works by this author on:Xiaochuan Wang;Xiaochuan WangNew York State Institute for Basic Research in Developmental DisabilitiesStaten Island, New YorkUSASearch for other works by this author on:Inge Grundke-IqbalInge Grundke-IqbalNew York State Institute for Basic Research in Developmental DisabilitiesStaten Island, New YorkUSASearch for other works by this author on:
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