Skip Nav Destination
Drug Discovery
Animal Models for Neurodegenerative Disease
Edited by
Jesus Avila;
Jesus Avila
Universidad Autonoma de Madrid, Spain
Search for other works by this author on:
Jose J Lucas;
Jose J Lucas
Universidad Autonoma de Madrid, Spain
Search for other works by this author on:
Felix Hernandez
Felix Hernandez
Universidad Autonoma de Madrid, Spain
Search for other works by this author on:
Hardback ISBN:
978-1-84973-184-3
PDF ISBN:
978-1-84973-275-8
Special Collection:
2011 ebook collection
,
2011 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery Series
No. of Pages:
306
Published online:
30 May 2011
Published in print:
24 May 2011
Book Chapter
Chapter 3: The Ying and Yang of the Reelin Signalling Pathway in Alzheimer's Disease Pathology
By
Eduardo Soriano
;
Eduardo Soriano
Development of Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona; Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED-ISCIII)
08028 Barcelona
Spain
Search for other works by this author on:
Daniela Rossi
;
Daniela Rossi
Development of Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona; Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED-ISCIII)
08028 Barcelona
Spain
Search for other works by this author on:
Lluís Pujadas
Lluís Pujadas
Development of Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona; Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED-ISCIII)
08028 Barcelona
Spain
Search for other works by this author on:
-
Published:24 May 2011
-
Special Collection: 2011 ebook collection , 2011 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery Series
Page range:
39 - 51
Citation
E. Soriano, D. Rossi, and L. Pujadas, in Animal Models for Neurodegenerative Disease, ed. J. Avila, J. J. Lucas, and F. Hernandez, The Royal Society of Chemistry, 2011, ch. 3, pp. 39-51.
Download citation file:
Reelin is an extracellular protein crucial for brain development. To study Reelin functions in the adult forebrain we generated a transgenic mouse model that overexpress Reelin under the control of the CaMKIIα promoter (pCaMKII-Reelin-OE; Tg1/Tg2)l. Studies on Tg1/Tg2 mice indicate that Reelin regulates adult neurogenesis and migration, as well as the structural and functional properties of synapses. These observations suggest that Reelin controls developmental processes that remain active in the adult brain.
This content is only available via PDF.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Digital access
$64.60