CHAPTER 22: Effects of Cationic Polymers on Cell Functions
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Published:14 Nov 2014
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Series: Polymer Chemistry Series
G. Chen, in Cationic Polymers in Regenerative Medicine, ed. S. K. Samal and P. Dubruel, The Royal Society of Chemistry, 2014, pp. 583-591.
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Cationic polymers can affect cell functions such as cell adhesion, proliferation and differentiation through electrostatic interaction with cells or mediated by protein adsorption. Their effects have been compared with cell culture polystyrene plates. The effects on chondrogenic and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells have been elucidated by culturing the cells under the presence of cationic polymers in soluble and grafted conditions. Cationic polymers show promotive effects on both osteogenic and chondrogenic differentiation, while polystyrene plates are good for osteogenic differentiation. This chapter summarizes and highlights the recent developments of cationic polymers on the functions of stem cells.