Chapter 23: Integrated Testing Strategies and the Prediction of Toxic Hazard Check Access

Over the past 20-30 years there has been a move towards reducing the use of animals in toxicity testing for industrial chemicals, pharmaceuticals, personal care and household products, for economic, scientific and animal welfare reasons. The need for alternatives has been emphasised by the EU REACH regulation, which requires the evaluation of tens of thousands of new and existing chemicals, and also within the pharmaceutical industry owing to the increasing rate at which drugs are being withdrawn from the market due to adverse effects not detected during preclinical testing. Significant effort is being placed into the development of non-animal test procedures using existing data, bioinformatics, in chemico, in silico and in vitro approaches and ethical human studies. Information from these diverse sources needs to be used intelligently and selectively leading to the development of what have become known as Integrated Testing Strategies (ITS). In this chapter factors that need to be considered in the development, evaluation, acceptance and use of ITS will be discussed.