Chapter 18: Biological Read-Across: Mechanistically-Based Species–Species and Endpoint–Endpoint Extrapolations Check Access
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Published:28 Oct 2010
M. T. D. Cronin, in In Silico Toxicology, ed. M. Cronin and J. Madden, The Royal Society of Chemistry, 2010, ch. 18, pp. 446-477.
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This chapter describes the development and use of relationships between toxicity data, for the same chemicals, derived from different species. These relationships provide simple models to predict toxicity of, potentially, a higher species from that of a lower species. Approaches to the formation of these models are described, notably inter-species relationships, quantitative structure-activity-activity relationships and prediction models. It is noted that the best extrapolations are for closely related species i.e. within taxa. In addition, forming groups or categories of compounds according to common mechanisms of toxic action improves the correlation for extrapolations from lower to higher species. A freely available software package, Web-ICE, is introduced as a suitable tool to apply these methods.
