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Stem Cell-Based Tissue Repair
Stem Cell-Based Tissue Repair
Edited by
Raphael Gorodetsky
Raphael Gorodetsky
Hebrew University Medical Center, Israel
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Richard Schäfer
Richard Schäfer
Stanford Institute for Neuro-Innovation and Translational Neurosciences, USA
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DOI:
https://doi.org/10.1039/9781849732246
Hardback ISBN:
978-1-84973-001-3
PDF ISBN:
978-1-84973-224-6
No. of Pages:
391
Publication date:
03 Dec 2010
Book Chapter

Chapter 7: Mesenchymal Stromal/Stem Cells from Tissue Repair to Destruction of Tumor Cells

By
Rita Bussolari
Rita Bussolari
Department of Oncology
Hematology and Respiratory Diseases
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;
Giulia Grisendi
Giulia Grisendi
Department of Oncology
Hematology and Respiratory Diseases
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;
Luigi Cafarelli
Luigi Cafarelli
Department of Oncology
Hematology and Respiratory Diseases
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;
Pietro Loschi
Pietro Loschi
Plastic Surgery Unit
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;
Laura Scarabelli
Laura Scarabelli
Department of Oncology
Hematology and Respiratory Diseases
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;
Antonio Frassoldati
Antonio Frassoldati
Department of Oncology
Hematology and Respiratory Diseases
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;
Michela Maur
Michela Maur
Department of Oncology
Hematology and Respiratory Diseases
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;
Giorgio De Santis
Giorgio De Santis
Plastic Surgery Unit
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;
Paolo Paolucci
Paolo Paolucci
Department of Mother and Child, University-Hospital of Modena and Reggio Emilia
Modena
Italy
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;
Pierfranco Conte
Pierfranco Conte
Department of Oncology
Hematology and Respiratory Diseases
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;
Massimo Dominici
Massimo Dominici
Department of Oncology
Hematology and Respiratory Diseases
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Doi:
https://doi.org/10.1039/9781849732246-00141
Page range:
141 - 158

Tumor stroma is a complex microenvironment composed of different cell types involved in the tumor initiation, promotion and progression. Therefore it may represent a suitable target in cancer therapy. Besides their known tissue repair potential, mesenchymal stromal/stem cells (MSCs) share several features with the tumor associated fibroblasts comprising the tumor stroma. In addition, MSCs can migrate towards tumors possibly impacting cancer cell progression. Based on these properties, MSCs can be used as cellular vehicles for gene therapy against tumors.

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