Stem Cell-Based Tissue Repair
Chapter 7: Mesenchymal Stromal/Stem Cells from Tissue Repair to Destruction of Tumor Cells
Published:03 Dec 2010
R. Bussolari, G. Grisendi, L. Cafarelli, P. Loschi, L. Scarabelli, A. Frassoldati, ... M. Dominici, in Stem Cell-Based Tissue Repair, ed. R. Gorodetsky and R. Schäfer, The Royal Society of Chemistry, 2010, ch. 7, pp. 141-158.
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Tumor stroma is a complex microenvironment composed of different cell types involved in the tumor initiation, promotion and progression. Therefore it may represent a suitable target in cancer therapy. Besides their known tissue repair potential, mesenchymal stromal/stem cells (MSCs) share several features with the tumor associated fibroblasts comprising the tumor stroma. In addition, MSCs can migrate towards tumors possibly impacting cancer cell progression. Based on these properties, MSCs can be used as cellular vehicles for gene therapy against tumors.