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The design of biomaterial-based heart tissue constructs have transformed tissue engineering into a promising approach toward advancing myocardial repair. Different technical strategies and potential biomaterials have been developed to promote this approach. Vascular therapy of the cardiac muscle could be modulated by endothelial progenitors cells derived from embryonic or stem cells from different sources. Based on these developments new approaches are proposed for optimization of vascularization of engineered tissues tissue in efforts to augment construct viability.

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