Stem Cell-Based Tissue Repair
Chapter 16: Regeneration of the Lower Urinary Tract: Clinical Applications and Future Outlook
Published:03 Dec 2010
M. Renninger, B. Amend, J. Seibold, G. Feil, A. Stenzl, and K. Sievert, in Stem Cell-Based Tissue Repair, ed. R. Gorodetsky and R. Schäfer, The Royal Society of Chemistry, 2010, ch. 16, pp. 324-345.
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Due to the absence of transplantable organ resources and the reconstructive urological demand, researchers have been called to action in order advance tissue engineering and stem cell research.
As the archetype of pluripotent cells, human embryonic stem cells (hESCs) and inducible stem cells (iPS) are still far from any clinical application, whereas new and interestingly adult sources of stem cells are coming into focus. Such urological reconstructive approaches such as adult myoblasts for an autologous therapy option of stress urinary incontinence and the recently advances in pluripotent adult human germline stem cells (haGSCs) have a potentially suitable application in male reconstructive medicine. Further and comparable progress must be made in the female approach. Despite its histological complexity, there has been a huge progression in the development of renal tissue formation. Even the feasibility of engineering the entire pendular penile corporal bodies in a rabbit model could be shown. The further development of suitable surgical harvesting and implantation techniques allow sufficient and functional graft survival.
Urological TE should be positioned as “a young field” that promises to influence urological treatment in the “near future”.