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Alzheimer's disease (AD) is an important neurodegenerative disorder for which no cure exists. It is a complex multifactorial syndrome. This opens up the possibility of achieving disease-modifying therapeutics by identifying ligands that possess a multi-target mechanism of action. Here, we report on memoquin, a novel multifunctional compound designed by inserting the benzoquinone nucleus of coenzyme Q into a polyamine scaffold. Detailed in vitro and in vivo investigations showed that memoquin combats AD on different fronts: it inhibits acetylcholinesterase, amyloid formation and aggregation, and also oxidative damage. These results indicate the potential for the development of multi-targeted drug candidates for the treatment of AD.

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