RNA Helicases
RNA helicases and RNA helicase-like proteins are the largest group of enzymes in eukaryotic RNA metabolism and although they are subject to intense ongoing research there is much confusion about function and classification of these enzymes. Although these enzymes are essential for virtually all processes involving RNA, there is no overview detailing structure, function and/or biological roles of these pivotal proteins. This book provides the first comprehensive and systematic overview of biology, mechanism, and structure of RNA helicases and RNA helicase-like enzymes. Research into RNA helicases takes place in many different fields from cell and developmental biology to mechanistic enzymology, and structural biology and this book integrates the knowledge of these diverse fields into one valuable resource. It also provides an informative overview on the entire group of enzymes. Individual chapters on each subfamily of RNA helicases and RNA helicase-like proteins are written by experts in the respective fields. All chapters are systematically integrated and the reader is guided by a didactic introductory chapter. The main strengths of the book are the combination of systematics and details that will allow the reader to gain insight into results from diverse fields while maintaining a view of the entire field. It will be a key reference for academics, advanced students, researchers and professionals working in or joining this field.
RNA Helicases, The Royal Society of Chemistry, 2010.
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Table of contents
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An Introduction to RNA Helicases: Superfamilies, Families, and Major Themesp1-31ByEckhard Jankowsky;Eckhard JankowskyDepartment of Biochemistry & Center for RNA Molecular BiologySchool of MedicineCase Western Reserve University10900 Euclid AveClevelandOH 44106USASearch for other works by this author on:Margaret E. Fairman-WilliamsMargaret E. Fairman-WilliamsDepartment of Biochemistry & Center for RNA Molecular BiologySchool of MedicineCase Western Reserve University10900 Euclid AveClevelandOH 44106USAcurrent address: Department of BiochemistryBrandeis UniversityWalthamMA 44106USASearch for other works by this author on:
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Chapter 2: The Dynamic Life with DEAD-Box RNA Helicasesp32-60ByPatrick LinderPatrick LinderDepartment of Microbiology and Molecular MedicineCMUUniversity of Geneva1211 Geneva 4SwitzerlandSearch for other works by this author on:
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Chapter 3: Mechanisms of DEAD-Box Proteins in ATP-Dependent Processesp61-98ByJeffrey P. Potratz;Jeffrey P. PotratzDepartment of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at AustinAustinTX 78712USASearch for other works by this author on:Pilar Tijerina;Pilar TijerinaDepartment of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at AustinAustinTX 78712USASearch for other works by this author on:Rick RussellRick RussellDepartment of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at AustinAustinTX 78712USASearch for other works by this author on:
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Chapter 4: The Biology of DEAH/RHA Proteins and Their Mechanism of Actionp99-120ByScott W. StevensScott W. StevensSection in Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at AustinAustinTX 78712USASearch for other works by this author on:
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Chapter 5: RIG-I-Like RNA Helicases: Multidomain Proteins in Antiviral Innate Immunity and Processing of Small Regulatory RNAsp121-148ByKarl-Peter Hopfner;Karl-Peter HopfnerGene Center, Center for Integrated Protein Sciences, Munich Center for Advanced Photonics, Department of Biochemistry, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str.2581377MunichGermanySearch for other works by this author on:Sheng Cui;Sheng CuiGene Center, Center for Integrated Protein Sciences, Munich Center for Advanced Photonics, Department of Biochemistry, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str.2581377MunichGermanySearch for other works by this author on:Axel Kirchhofer;Axel KirchhoferGene Center, Center for Integrated Protein Sciences, Munich Center for Advanced Photonics, Department of Biochemistry, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str.2581377MunichGermanySearch for other works by this author on:Diana PippigDiana PippigGene Center, Center for Integrated Protein Sciences, Munich Center for Advanced Photonics, Department of Biochemistry, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str.2581377MunichGermanySearch for other works by this author on:
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Chapter 6: Ski2-Like Proteins: Biology and Mechanismp149-167ByMark G. CapraraMark G. CapraraCenter for RNA Molecular Biology and Department of Biochemistry, Case Western Reserve University, School of Medicine10900 EuclidAveClevelandOH 44106-4960USASearch for other works by this author on:
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Chapter 7: Viral DExH Proteins, the NS3/NPH-II Familyp168-188ByMargaret E. Fairman-Williams;Margaret E. Fairman-WilliamsDepartment of BiochemistryBrandeis UniversityWalthamMAUSASearch for other works by this author on:Eckhard JankowskyEckhard JankowskyDepartment of Biochemistry and Center for RNA Molecular Biology, School of Medicine, Case Western Reserve UniversityClevelandOHUSASearch for other works by this author on:
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Chapter 8: Superfamily 1 RNA Helicases: Biology and Mechanismp189-212ByPortia Gloria Loh;Portia Gloria LohCancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)61 Biopolis DriveSingapore138673SingaporeSearch for other works by this author on:Haiwei SongHaiwei SongCancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)61 Biopolis DriveSingapore138673SingaporeSearch for other works by this author on:
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Chapter 9: Hexameric Viral RNA Helicasesp213-242ByRoman TumaRoman TumaThe Astbury Centre for Structural Molecular Biology, Institute of Cellular and Molecular Biology, University of LeedsLeedsUKSearch for other works by this author on:
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Chapter 10: Transcription Termination Factor Rho: A Ring-Shaped RNA Helicase from Bacteriap243-271ByMakhlouf Rabhi;Makhlouf RabhiCentre de Biophysique Moléculaire (UPR4301)CNRSrue Charles Sadron45071 Orléans cedex 2FranceEcole doctorale Sciences et Technologies, Université d’OrléansFranceSearch for other works by this author on:A. Rachid Rahmouni;A. Rachid RahmouniCentre de Biophysique Moléculaire (UPR4301)CNRSrue Charles Sadron45071 Orléans cedex 2FranceSearch for other works by this author on:Marc BoudvillainMarc BoudvillainCentre de Biophysique Moléculaire (UPR4301)CNRSrue Charles Sadron45071 Orléans cedex 2FranceSearch for other works by this author on:
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