Metal Ions in Toxicology
2: Human Risk Assessment of Heavy Metals: Principles and Applications
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Published:11 Nov 2010
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Special Collection: 2010 ebook collection , 2000-2010 biosciences subject collection , 2010 biosciences subject collection
Jean-Lou C. M. Dorne, George E. N. Kass, Luisa R. Bordajandi, Billy Amzal, Ulla Bertelsen, Anna F. Castoldi, Claudia Heppner, Mari Eskola, Stefan Fabiansson, Pietro Ferrari, Elena Scaravelli, Eugenia Dogliotti, Peter Fuerst, Alan R. Boobis, Philippe Verger, 2010. "Human Risk Assessment of Heavy Metals: Principles and Applications", Metal Ions in Toxicology, Hana R Pohl, Michael P Waalkes, Rolf Altenburger, Jean-Lou C. M. Dorne, Moiz Mumtaz, Antonio Mutti, Declan P. Naughton, Bruce Fowler, Bruce Fowler, Irina Lehmann, Alan B. G. Lansdown, Pietro Apostoli, Andreas Kortenkamp, Woijciech Bal, Astrid Sigel, Helmut Sigel, Roland K O Sigel, Astrid Sigel, Helmut Sigel, Roland K O Sigel, Astrid Sigel, Helmut Sigel, Roland K O Sigel, Astrid Sigel, Helmut Sigel, Roland K O Sigel, Astrid Sigel, Helmut Sigel, Roland K O Sigel
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Humans are exposed to a number of “heavy metals” such as cadmium, mercury and its organic form methylmercury, uranium, lead, and other metals as well as metalloids, such as arsenic, in the environment, workplace, food, and water supply. Exposure to these metals may result in adverse health effects, and national and international health agencies have methodologies to set health-based guidance values with the aim to protect the human population. This chapter introduces the general principles of chemical risk assessment, the common four steps of chemical risk assessment: hazard identification, hazard characterization, exposure assessment, risk characterization, and toxicokinetic and toxicity aspects. Finally, the risk assessments performed by international health agencies such as the World Health Organisation, the Environmental Protection Agency of the United States, and the European Food Safety Authority are reviewed for cadmium, lead, mercury, uranium, and arsenic.
Humans are exposed to a number of “heavy metals” such as cadmium, mercury and its organic form methylmercury, uranium, lead, and other metals as well as metalloids, such as arsenic, in the environment, workplace, food, and water supply. Exposure to these metals may result in adverse health effects, and national and international health agencies have methodologies to set health-based guidance values with the aim to protect the human population. This chapter introduces the general principles of chemical risk assessment, the common four steps of chemical risk assessment: hazard identification, hazard characterization, exposure assessment, risk characterization, and toxicokinetic and toxicity aspects. Finally, the risk assessments performed by international health agencies such as the World Health Organisation, the Environmental Protection Agency of the United States, and the European Food Safety Authority are reviewed for cadmium, lead, mercury, uranium, and arsenic.
Humans are exposed to a number of “heavy metals” such as cadmium, mercury and its organic form methylmercury, uranium, lead, and other metals as well as metalloids, such as arsenic, in the environment, workplace, food, and water supply. Exposure to these metals may result in adverse health effects, and national and international health agencies have methodologies to set health-based guidance values with the aim to protect the human population. This chapter introduces the general principles of chemical risk assessment, the common four steps of chemical risk assessment: hazard identification, hazard characterization, exposure assessment, risk characterization, and toxicokinetic and toxicity aspects. Finally, the risk assessments performed by international health agencies such as the World Health Organisation, the Environmental Protection Agency of the United States, and the European Food Safety Authority are reviewed for cadmium, lead, mercury, uranium, and arsenic.
Humans are exposed to a number of “heavy metals” such as cadmium, mercury and its organic form methylmercury, uranium, lead, and other metals as well as metalloids, such as arsenic, in the environment, workplace, food, and water supply. Exposure to these metals may result in adverse health effects, and national and international health agencies have methodologies to set health-based guidance values with the aim to protect the human population. This chapter introduces the general principles of chemical risk assessment, the common four steps of chemical risk assessment: hazard identification, hazard characterization, exposure assessment, risk characterization, and toxicokinetic and toxicity aspects. Finally, the risk assessments performed by international health agencies such as the World Health Organisation, the Environmental Protection Agency of the United States, and the European Food Safety Authority are reviewed for cadmium, lead, mercury, uranium, and arsenic.