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Drug Discovery
Designing Multi-Target Drugs
Hardback ISBN:
978-1-84973-362-5
PDF ISBN:
978-1-84973-491-2
Special Collection:
2012 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery
No. of Pages:
394
Publication date:
28 Mar 2012
Book Chapter
Chapter 9: In Silico Lead Generation Approaches in Multi-Target Drug Discovery
By
Xiaohou Ma
;
Xiaohou Ma
Bioinformatics and Drug Design Group
Department of Pharmacy, Centre for Computational Science and Engineering, National University of Singapore
Blk S16, Level 8, 3 Science Drive 2
Singapore 117543
phacyz@nus.edu.sg
Search for other works by this author on:
Yuzong Chen
Yuzong Chen
Bioinformatics and Drug Design Group
Department of Pharmacy, Centre for Computational Science and Engineering, National University of Singapore
Blk S16, Level 8, 3 Science Drive 2
Singapore 117543
phacyz@nus.edu.sg
Search for other works by this author on:
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Published:28 Mar 2012
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Special Collection: 2012 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery
Citation
Xiaohou Ma, Yuzong Chen, 2012. "In Silico Lead Generation Approaches in Multi-Target Drug Discovery", Designing Multi-Target Drugs, J. Richard Morphy, C John Harris
Download citation file:
Increasingly sophisticated in silico screening methods are being applied to facilitate MTDD at the hit generation and optimization stages. Structure-based and ligand-based methods have been used individually and in combination to identify novel compounds. These will be described in this chapter and a number of examples will be provided.
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