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Drug Discovery
Designing Multi-Target Drugs
Hardback ISBN:
978-1-84973-362-5
PDF ISBN:
978-1-84973-491-2
Special Collection:
2012 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery
No. of Pages:
394
Published online:
28 Mar 2012
Published in print:
12 Apr 2012
Book Chapter
Chapter 9: In Silico Lead Generation Approaches in Multi-Target Drug Discovery
By
Xiaohou Ma
;
Xiaohou Ma
Bioinformatics and Drug Design Group
Department of Pharmacy, Centre for Computational Science and Engineering, National University of Singapore
Blk S16, Level 8, 3 Science Drive 2
Singapore 117543
[email protected]
Search for other works by this author on:
Yuzong Chen
Yuzong Chen
Bioinformatics and Drug Design Group
Department of Pharmacy, Centre for Computational Science and Engineering, National University of Singapore
Blk S16, Level 8, 3 Science Drive 2
Singapore 117543
[email protected]
Search for other works by this author on:
-
Published:28 Mar 2012
-
Special Collection: 2012 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery
Page range:
130 - 140
Citation
X. Ma and Y. Chen, in Designing Multi-Target Drugs, ed. J. R. Morphy and C. J. Harris, The Royal Society of Chemistry, 2012, ch. 9, pp. 130-140.
Download citation file:
Increasingly sophisticated in silico screening methods are being applied to facilitate MTDD at the hit generation and optimization stages. Structure-based and ligand-based methods have been used individually and in combination to identify novel compounds. These will be described in this chapter and a number of examples will be provided.
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