New Frontiers in Chemical Biology
Despite ever-increasing investment in biomedical research, there has been a significant decline in the number of new drug approvals in recent years. In an effort to improve productivity, the drug discovery community has increasingly looked to biotherapeutics such as antibodies, vaccines, nucleic acids, and peptides.
Chemical biology is an emerging field at the interface between chemistry and biology. It utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing the productivity challenges expressed above. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules involved in many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is a key discipline within 21st century drug discovery and the purpose of this book is to highlight the most important developments. It provides a valuable resource for scientists in academia and industry who are looking to build their knowledge of this hot topic.
The individual chapters cover crucial areas including chemical proteomics, chemical genetics, post-translational modifications, epigenetics, RNA interference, PROTACS, antibody-drug conjugates, and chemologics.
New Frontiers in Chemical Biology, The Royal Society of Chemistry, 2010.
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Table of contents
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The Chemical Genetic Approach: The Interrogation of Biological Mechanisms with Small Molecule Probesp1-32ByMartin Fisher;Martin FisherSchool of Chemistry, University of LeedsLeedsUKLS2 9JTAstbury Centre for Structural Molecular Biology, University of LeedsLeedsUKLS2 9JTSearch for other works by this author on:Adam NelsonAdam NelsonSchool of Chemistry, University of LeedsLeedsUKLS2 9JTAstbury Centre for Structural Molecular Biology, University of LeedsLeedsUKLS2 9JTSearch for other works by this author on:
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Chapter 2: Applications for Activity-based Probes in Drug Discoveryp33-63ByL.E. Edgington;L.E. EdgingtonDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur DriveStanfordCA 94305USASearch for other works by this author on:M. BogyoM. BogyoDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur DriveStanfordCA 94305USADepartment of Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur DriveStanfordCA 94305USASearch for other works by this author on:
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Chapter 3: Targeted Intracellular Protein Degradation as a Potential Therapeutic Strategyp64-96ByA.R. Schneekloth;A.R. SchneeklothDepartment of ChemistryYale University, PO Box 208107New HavenCT 06520-8107USASearch for other works by this author on:C.M. CrewsC.M. CrewsDepartment of ChemistryYale University, PO Box 208107New HavenCT 06520-8107USADepartment of Molecular, Cellular, and Developmental BiologyYale University, PO Box 208103New HavenCT 06520-8103USADepartment of PharmacologyYale University, PO Box 208103New HavenCT 06520-8103USASearch for other works by this author on:
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Chapter 4: Chemical Biology of Stem Cell Modulationp97-150ByStephen G. Davies;Stephen G. DaviesDepartment of Chemistry, Chemistry Research Laboratory, University of OxfordMansfield RoadOxford OX1 3TAUKSearch for other works by this author on:Angela J. RussellAngela J. RussellDepartment of Chemistry, Chemistry Research Laboratory, University of OxfordMansfield RoadOxford OX1 3TAUKDepartment of Pharmacology, University of OxfordMansfield RoadOxford OX1 3QTUKSearch for other works by this author on:
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Chapter 5: Chemical Biology of Histone Modificationsp151-203ByNathan R. Rose;Nathan R. RoseThe Department of Chemistry and the Oxford Centre for Integrative Systems BiologyChemistry Research Laboratory, University of Oxford, 12 Mansfield RoadOxfordUKOX1 3TASearch for other works by this author on:Christopher J. Schofield;Christopher J. SchofieldThe Department of Chemistry and the Oxford Centre for Integrative Systems BiologyChemistry Research Laboratory, University of Oxford, 12 Mansfield RoadOxfordUKOX1 3TASearch for other works by this author on:Tom D. HeightmanTom D. HeightmanStructural Genomics ConsortiumUniversity of Oxford, Old Road Campus, Roosevelt Drive, HeadingtonOxfordUKOX3 7DQSearch for other works by this author on:
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Chapter 6: Chemologicsp204-223ByLyn H. JonesLyn H. JonesPfizer Inc.Sandwich Laboratories ipc 432, SandwichKent, CT13 9NJUKSearch for other works by this author on:
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Chapter 7: Antibody–Drug Conjugates in Oncologyp224-257ByPhilip R. Hamann;Philip R. HamannJohn Jay College of Criminal JusticeNew YorkNY 10019USASearch for other works by this author on:Russell G. DushinRussell G. DushinMS 220-3516, Pfizer, Inc., 445 Eastern Point RoadGrotonCT 06340USASearch for other works by this author on:
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Chapter 8: Drug Discovery by DNA-encoded Librariesp258-302ByYizhou Li;Yizhou LiBeijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Organic ChemistryCollege of Chemistry and Chemical Engineering, Peking UniversityBeijingChina100871Search for other works by this author on:Zheng Zhu;Zheng ZhuBeijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Organic ChemistryCollege of Chemistry and Chemical Engineering, Peking UniversityBeijingChina100871Search for other works by this author on:Xiaoyu LiXiaoyu LiBeijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Organic ChemistryCollege of Chemistry and Chemical Engineering, Peking UniversityBeijingChina100871Search for other works by this author on:
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