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In the past decade, drug discovery has been plagued by the lack of tools capable of exploring the vast chemical space to interrogate all the available drug targets in order to treat diseases more effectively. In the past decade, DNA-encoded library has emerged as one of the unique approaches to address this issue by incorporating Nature's evolutional strategy in discovery of small molecule functions. A variety of drug discovery platforms based on this approach have been created in pharmaceutical companies. In this chapter, we will first discuss the fundamental mechanisms underlying DNA-encoded library; and in the second half, we will discuss the variations and industrialization of this technology, and its potential to become one of the indispensable tool in modern drug discovery.

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