N-Heterocyclic Carbenes
Over the last fifteen years, N-heterocyclic carbenes (NHCs) have mostly been used as ancillary ligands for the preparation of transition metal-based catalysts. Compared to phosphorus-containing ligands, NHCs tend to bind more strongly to metal centres, avoiding the necessity for the use of excess ligand in catalytic reactions. The corresponding complexes are often less sensitive to air and moisture, and have proven remarkably resistant to oxidation. Recent developments in catalysis applications have been facilitated by the availability of carbenes stable enough to be bottled, particularly for their use as organocatalysts. This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium-catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Moreover, the biological activity of NHC-containing complexes, as well as an overview of their theoretical aspects are included. Such metal species are further examined, not only in terms of their catalytic applications, but also of their stereoelectronic parameters and reactivity/stability. Finally, special attention is given to the hot topic of organocatalysis. The book will be of interest to postgraduates, academic researchers and those working in industry.
N-Heterocyclic Carbenes, The Royal Society of Chemistry, 2010.
Download citation file:
Digital access
Print format
Table of contents
-
Introduction to N-Heterocyclic Carbenes: Synthesis and Stereoelectronic Parametersp1-41ByMareike C. Jahnke;Mareike C. JahnkeInstitut für Anorganische und Analytische ChemieWestfälische Wilhelms-Universität Münster, Corrensstrasse 30D-48149 MünsterGermanySearch for other works by this author on:F. Ekkehardt HahnF. Ekkehardt HahnInstitut für Anorganische und Analytische ChemieWestfälische Wilhelms-Universität Münster, Corrensstrasse 30D-48149 MünsterGermanySearch for other works by this author on:
-
Chapter 2: Computational Studies on the Reactivity of Transition Metal Complexes Featuring N-Heterocyclic Carbene Ligandsp42-76ByL. Jonas L. Häller;L. Jonas L. HällerSchool of Engineering and Physical Sciences, Perkin Building, Heriot–Watt UniversityEdinburgh EH14 4ASUKSearch for other works by this author on:Stuart A. Macgregor;Stuart A. MacgregorSchool of Engineering and Physical Sciences, Perkin Building, Heriot–Watt UniversityEdinburgh EH14 4ASUKSearch for other works by this author on:Julien A. PanetierJulien A. PanetierSchool of Engineering and Physical Sciences, Perkin Building, Heriot–Watt UniversityEdinburgh EH14 4ASUKSearch for other works by this author on:
-
Chapter 3: Synthesis, Activation and Decomposition of N-Heterocyclic Carbene-containing Complexesp77-118ByJeremy M. Praetorius;Jeremy M. PraetoriusQueen's UniversityChernoff Hall, 90 Bader Lane, KingstonOntarioK7L 3N6CanadaSearch for other works by this author on:Cathleen M. CruddenCathleen M. CruddenQueen's UniversityChernoff Hall, 90 Bader Lane, KingstonOntarioK7L 3N6CanadaSearch for other works by this author on:
-
Chapter 4: Biologically Active N-Heterocyclic Carbene–Metal Complexesp119-133ByMichael C. Deblock;Michael C. DeblockCenter for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of AkronAkronOhio 44325-3601USASearch for other works by this author on:Matthew J. Panzner;Matthew J. PanznerCenter for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of AkronAkronOhio 44325-3601USASearch for other works by this author on:Claire A. Tessier;Claire A. TessierCenter for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of AkronAkronOhio 44325-3601USASearch for other works by this author on:Carolyn L. Cannon;Carolyn L. CannonSchool of Medicine, Pediatrics, University of Texas Southwestern Medical CenterDallasTexas 75390USASearch for other works by this author on:Wiley J. YoungsWiley J. YoungsCenter for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of AkronAkronOhio 44325-3601USASearch for other works by this author on:
-
Chapter 5: Non-classical N-Heterocyclic Carbene Complexesp134-165ByAnneke Krüger;Anneke KrügerUniversity College Dublin, School of Chemistry and Chemical BiologyBelfieldDublin 4IrelandSearch for other works by this author on:
-
Chapter 6: Early Transition and Rare Earth Metal Complexes with N-Heterocyclic Carbenesp166-195ByLars-Arne Schaper;Lars-Arne SchaperTechnische Universität MünchenLichtenbergstr. 4D-85747 Garching bei MünchenGermanySearch for other works by this author on:Evangeline Tosh;Evangeline ToshTechnische Universität MünchenLichtenbergstr. 4D-85747 Garching bei MünchenGermanySearch for other works by this author on:Wolfgang A. HerrmannWolfgang A. HerrmannTechnische Universität MünchenLichtenbergstr. 4D-85747 Garching bei MünchenGermanySearch for other works by this author on:
-
Chapter 7: NHC–Iron, Ruthenium and Osmium Complexes in Catalysisp196-227ByLionel Delaude;Lionel DelaudeLaboratory of Macromolecular Chemistry and Organic Catalysis, Institut de Chimie (B6a), Université de LiègeSart-Tilman4000 LiègeBelgiumSearch for other works by this author on:Albert DemonceauAlbert DemonceauLaboratory of Macromolecular Chemistry and Organic Catalysis, Institut de Chimie (B6a), Université de LiègeSart-Tilman4000 LiègeBelgiumSearch for other works by this author on:
-
Chapter 8: NHC–Cobalt, Rhodium and Iridium Complexes in Catalysisp228-251ByVincent César;Vincent CésarLaboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne31077 Toulouse Cedex 4FranceSearch for other works by this author on:Lutz H. Gade;Lutz H. GadeAnorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 27069120 HeidelbergGermanySearch for other works by this author on:Stéphane Bellemin-LaponnazStéphane Bellemin-LaponnazInstitut de Physique et Chimie des Matériaux de Strasbourg, CNRS-Université de Strasbourg, 23 Rue du Loess67034 StrasbourgFranceSearch for other works by this author on:
-
Chapter 9: NHC–Palladium Complexes in Catalysisp252-283ByAdrien T. Normand;Adrien T. NormandDepartment of Chemistry, University of Ottawa10 Marie Curie StreetK1N 6N5Ottawa, ONCanadaSearch for other works by this author on:Kingsley J. CavellKingsley J. CavellSchool of Chemistry, Cardiff University51 Park PlaceCF10 3ATCardiffUKSearch for other works by this author on:
-
Chapter 10: NHC–Nickel and Platinum Complexes in Catalysisp284-326ByYves Fort;Yves FortLaboratoire SRSMC-SOR, UMR CNRS-UHP 7565, Nancy Université, BP 70239, Bd des Aiguillettes54506 Vandoeuvre-les-NancyFranceSearch for other works by this author on:Corinne ComoyCorinne ComoyLaboratoire SRSMC-SOR, UMR CNRS-UHP 7565, Nancy Université, BP 70239, Bd des Aiguillettes54506 Vandoeuvre-les-NancyFranceSearch for other works by this author on:
-
Chapter 11: NHC–Copper, Silver and Gold Complexes in Catalysisp317-344ByNicolas Marion*Nicolas Marion*Department of Chemistry, Massachusetts Institute of Technology77 Massachusetts AvenueCambridge, MA 02139USASearch for other works by this author on:
-
Chapter 12: Oxidation Reactions with NHC–Metal Complexesp345-365BySusanne M. Podhajsky;Susanne M. PodhajskyDepartment of ChemistryUniversity of Utah, 315 South 1400 EastSalt Lake CityUtah 84112USASearch for other works by this author on:Matthew S. SigmanMatthew S. SigmanDepartment of ChemistryUniversity of Utah, 315 South 1400 EastSalt Lake CityUtah 84112USASearch for other works by this author on:
-
Chapter 13: Reduction Reactions with NHC-bearing Complexesp366-398ByBekir ÇetinkayaBekir ÇetinkayaEge University, Department of Chemistry, 35100, BornovaIzmirTurkeySearch for other works by this author on:
-
Chapter 14: N-Heterocyclic Carbenes as Organic Catalystsp399-435ByPei-Chen Chiang;Pei-Chen ChiangDepartment of ChemistryUniversity of Pennsylvania, 231 S. 34th StPhiladelphiaPA 19104USASearch for other works by this author on:Jeffrey W. Bode*Jeffrey W. Bode*Department of ChemistryUniversity of Pennsylvania, 231 S. 34th StPhiladelphiaPA 19104USASearch for other works by this author on:
Spotlight
Advertisement
Advertisement