Chapter 4: Biologically Active N-Heterocyclic Carbene–Metal Complexes
Published:26 Nov 2010
M. C. Deblock, M. J. Panzner, C. A. Tessier, C. L. Cannon, and W. J. Youngs, in N-Heterocyclic Carbenes, ed. S. Diez-Gonzalez, The Royal Society of Chemistry, 2010, ch. 4, pp. 119-133.
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The increasing popularity of N-heterocyclic carbenes (NHCs) has yield in the past few years numerous new and exciting applications of these species, particularly as ligands in metal complexes. Complementarily, these ligands could have a prominent role in the development of new metallopharmaceuticals. Thanks to the number of different NHC–metal compounds that can be synthesized a wide variety of applications have emerged as bio-inorganic pharmaceuticals. Medicinal uses studied so far include powerful broad spectrum antibiotics and targeted antitumor agents.