Photodynamic Inactivation of Microbial Pathogens: Medical and Environmental Applications
Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.
Photodynamic Inactivation of Microbial Pathogens: Medical and Environmental Applications, The Royal Society of Chemistry, 2011.
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Table of contents
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Antimicrobial Photodynamic Therapy: Basic Principlesp1-18ByGiulio Jori;Giulio JoriDepartment of Biology, University of PadovaVia Ugo Bassi 58B35131PadovaItalySearch for other works by this author on:Monica Camerin;Monica CamerinDepartment of Biology, University of PadovaVia Ugo Bassi 58B35131PadovaItalySearch for other works by this author on:Marina Soncin;Marina SoncinDepartment of Biology, University of PadovaVia Ugo Bassi 58B35131PadovaItalySearch for other works by this author on:Laura Guidolin;Laura GuidolinDepartment of Biology, University of PadovaVia Ugo Bassi 58B35131PadovaItalySearch for other works by this author on:Olimpia CoppellottiOlimpia CoppellottiDepartment of Biology, University of PadovaVia Ugo Bassi 58B35131PadovaItalySearch for other works by this author on:
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Chapter 2: Phenothiazinium Salts as Antimicrobial Photosensitizing Agentsp19-43ByMark WainwrightMark WainwrightSchool of Pharmacy & Biomolecular ScienceLiverpool John Moores UniversityLiverpool L3 3AFUKSearch for other works by this author on:
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Chapter 3: Approaches to Kill Gram-negative Bacteria by Photosensitized Processesp45-67ByYeshayahu Nitzan;Yeshayahu NitzanThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan UniversityRamat-Gan 52900IsraelSearch for other works by this author on:Izabella PechatnikovIzabella PechatnikovThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan UniversityRamat-Gan 52900IsraelSearch for other works by this author on:
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Chapter 4: Innovative Design of Antimicrobial Photosensitizersp69-82ByMichael R. Hamblin;Michael R. HamblinWellman Center for Photomedicine, Massachusetts General HospitalBoston, MA02114USADepartment of Dermatology, Harvard Medical SchoolBoston, MA02115USAHarvard-MIT Division of Health Sciences and TechnologyCambridge, MA02139USASearch for other works by this author on:Sulbha K. Sharma;Sulbha K. SharmaWellman Center for Photomedicine, Massachusetts General HospitalBoston, MA02114USASearch for other works by this author on:Gitika B. KharkwalGitika B. KharkwalWellman Center for Photomedicine, Massachusetts General HospitalBoston, MA02114USADepartment of Dermatology, Harvard Medical SchoolBoston, MA02115USASearch for other works by this author on:
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Chapter 5: Porphyrins as Antimicrobial Photosensitizing Agentsp83-160ByA. Almeida;A. AlmeidaCESAM & Department of BiologyUniversity of Aveiro3810-193AveiroPortugalSearch for other works by this author on:A. Cunha;A. CunhaCESAM & Department of BiologyUniversity of Aveiro3810-193AveiroPortugalSearch for other works by this author on:M. A. F. Faustino;M. A. F. FaustinoQOPNA & Department of ChemistryUniversity of Aveiro3810-193AveiroPortugalSearch for other works by this author on:A. C. Tomé;A. C. ToméQOPNA & Department of ChemistryUniversity of Aveiro3810-193AveiroPortugalSearch for other works by this author on:M. G. P. M. S. NevesM. G. P. M. S. NevesQOPNA & Department of ChemistryUniversity of Aveiro3810-193AveiroPortugalSearch for other works by this author on:
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Chapter 6: Fullerene Derivatives as Antimicrobial Photosensitizing Agentsp161-184ByM. Elisa Milanesio;M. Elisa MilanesioDepartamento de Química, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río CuartoAgencia Postal Nro. 3, X5804BYA Río CuartoCórdobaArgentinaSearch for other works by this author on:Edgardo N. DurantiniEdgardo N. DurantiniDepartamento de Química, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río CuartoAgencia Postal Nro. 3, X5804BYA Río CuartoCórdobaArgentinaSearch for other works by this author on:
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Chapter 7: Photosensitizer Delivery for Photodynamic Antimicrobial Chemotherapyp185-216ByRyan F. Donnelly;Ryan F. DonnellySchool of Pharmacy, Queen's University Belfast, Medical Biology Centre97 Lisburn Road, Belfast BT9 7BLUKSearch for other works by this author on:Corona M. Cassidy;Corona M. CassidySchool of Pharmacy, Queen's University Belfast, Medical Biology Centre97 Lisburn Road, Belfast BT9 7BLUKSearch for other works by this author on:Michael M. TunneyMichael M. TunneySchool of Pharmacy, Queen's University Belfast, Medical Biology Centre97 Lisburn Road, Belfast BT9 7BLUKSearch for other works by this author on:
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Chapter 8: Photodynamic Therapy of Localized Infections in Animal Modelsp217-232ByTianhong Dai;Tianhong DaiWellman Center for PhotomedicineMassachusetts General HospitalBoston, MA02114USADepartment of DermatologyHarvard Medical SchoolBoston, MA02114USASearch for other works by this author on:Michael R. HamblinMichael R. HamblinWellman Center for PhotomedicineMassachusetts General HospitalBoston, MA02114USADepartment of DermatologyHarvard Medical SchoolBoston, MA02114USAHarvard-MIT Division of Health Sciences and TechnologyCambridge, MA02139USASearch for other works by this author on:
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Chapter 9: Pathogen Reduction in Blood for Transfusion Using Photodynamic Treatmentsp233-263ByEhud Ben-Hur;Ehud Ben-HurConsultant in blood safety and photomedicine3209 Huckleberry Way, Loveland, CO80538USASearch for other works by this author on:Raymond P. GoodrichRaymond P. GoodrichChief Science Officer, CaridianBCT Biotechnologies LLCLakewood, CO80215USASearch for other works by this author on:
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Chapter 10: PDT for Acnep265-289ByMichael H. GoldMichael H. GoldMedical Director, Gold Skin Care Center, Tennessee Clinical Research Center, Clinical Assistant Professor, Vanderbilt University School of Medicine, Department of DermatologyVanderbilt University School of NursingNashville, TNUSAVisiting Professor of DermatologyHuashan Hospital, Fudan University, ShanghaiChinaNo. 1 Hospital of China Medical UniversityShenyangChinaSearch for other works by this author on:
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Chapter 11: PDT for Viral Lesionsp291-301ByMichael H. GoldMichael H. GoldMedical Director, Gold Skin Care Center, Tennessee Clinical Research Center, Clinical Assistant Professor, Vanderbilt University School of Medicine, Department of DermatologyVanderbilt University School of NursingNashville, TNUSAVisiting Professor of DermatologyHuashan Hospital, Fudan University, ShanghaiChinaNo. 1 Hospital of China Medical UniversityShenyangChinaSearch for other works by this author on:
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Chapter 12: PDT for Cutaneous Leishmaniasisp303-326ByOleg E. Akilov;Oleg E. AkilovInstructor, Department of Dermatology, University of Pittsburgh200 Lothrop Street, Presbyterian South Tower, Suite3880Pittsburgh, PA15213USASearch for other works by this author on:Ulysses W. Sallum;Ulysses W. SallumResearch Fellow, Department of Dermatology, Harvard Medical SchoolWellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom StreetBoston, MA02114USASearch for other works by this author on:Tayyaba HasanTayyaba HasanProfessor, Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital40 Blossom StreetBoston, MA02114USASearch for other works by this author on:
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Chapter 13: Antimicrobial Photodynamic Therapy (aPDT) for Oral Infectionsp327-360ByJonathan Pratten;Jonathan PrattenMicrobial Diseases Research Department, UCL Eastman Dental Institute256 Gray's Inn RoadLondonWC1X 8LDUKSearch for other works by this author on:Veronique Benhamou;Veronique BenhamouMcGill University Dental SchoolMontreal, QuebecCanadaSearch for other works by this author on:Cale StreetCale StreetOndine Biopharma Corporation19017-120th Ave NEBothell, WA98011USASearch for other works by this author on:
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Chapter 14: Photodynamic Antifungal Chemotherapyp361-375ByP. G. Calzavara-Pinton;P. G. Calzavara-PintonDepartment of Dermatology, Spedali Civili HospitalP. le Spedali Civili 125123BresciaItalySearch for other works by this author on:M. T. Rossi;M. T. RossiDepartment of Dermatology, Spedali Civili HospitalP. le Spedali Civili 125123BresciaItalySearch for other works by this author on:B. OrtelB. OrtelSection of Dermatology, University of Chicago5841 S. MarylandChicago, IL60615USASearch for other works by this author on:
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Chapter 15: Photodynamic Therapy for Wound Infectionsp377-388ByStanley B. Brown;Stanley B. BrownInstitute of Molecular and Cell Biology, Faculty of Biological Sciences, University of LeedsLeedsLS2 9JTUKPhotopharmica Ltd, Leeds Innovation Centre103 Clarendon RoadLeedsLS2 9DFUKSearch for other works by this author on:Clare L. ConwayClare L. ConwayPhotopharmica Ltd, Leeds Innovation Centre103 Clarendon RoadLeedsLS2 9DFUKSearch for other works by this author on:
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Chapter 16: Photodynamic Therapy for Helicobacter pylori Infectionsp389-401ByJavad T. Hashmi;Javad T. HashmiWellman Center for Photomedicine, Massachusetts General HospitalBoston, MA02114USADepartment of Dermatology, Harvard Medical SchoolBoston, MA02114USASearch for other works by this author on:Michael R. HamblinMichael R. HamblinWellman Center for Photomedicine, Massachusetts General HospitalBoston, MA02114USADepartment of Dermatology, Harvard Medical SchoolBoston, MA02114USAHarvard-MIT Division of Health Sciences and TechnologyCambridge, MA02139USASearch for other works by this author on:
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Chapter 17: Inactivation of Microbial Pathogens by Photosensitized Processes: Environmental Applicationsp403-423ByMichela Magaraggia;Michela MagaraggiaDepartment of BiologyUniversity of PadovaItalySearch for other works by this author on:Olimpia Coppellotti;Olimpia CoppellottiDepartment of BiologyUniversity of PadovaItalySearch for other works by this author on:Clara Fabris;Clara FabrisDepartment of BiologyUniversity of PadovaItalySearch for other works by this author on:Laura Guidolin;Laura GuidolinDepartment of BiologyUniversity of PadovaItalySearch for other works by this author on:Giulio JoriGiulio JoriDepartment of BiologyUniversity of PadovaItalySearch for other works by this author on:
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