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Nanoscience & Nanotechnology Series
Unravelling Single Cell Genomics
By
Severine le Gac;
Severine le Gac
University of Twente, Netherlands
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Royal Society of Chemistry
Royal Society of Chemistry
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Edited by
Nathalie Bontoux;
Nathalie Bontoux
Agilent Technologies, France
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Harold Craighead;
Harold Craighead
Cornell University, USA
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Paul O'Brien
Paul O'Brien
University of Manchester, UK
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Hardback ISBN:
978-1-84755-911-1
PDF ISBN:
978-1-84973-228-4
No. of Pages:
336
Publication date:
18 Oct 2010
About this book
This unique introduction to the growing field of microfluidics applied to genomics provides an overview of the latest technologies and emphasizes its potential in answering important biological questions. Written by a physicist and a biologist, it offers a more comprehensive view than the previous literature. The book starts with key ideas in molecular biology, developmental biology and microtechnology before going on to cover the specifics of single cell analysis and microfluidic devices for single cell molecular analysis. Review chapters discuss the state-of-the art and will prove invaluable to all those planning to develop microdevices for molecular analysis of single cells. Methods allowing complete analysis of gene expression in the single cell are stressed - as opposed the more commonly used techniques that allow analysis of only a few genes at a time. As pioneers in the field, the authors understand how critical it is for a physicist to understand the biological issues and questions related to single cell analysis, as well for biologists to understand what microfluidics is all about. Aimed predominantly at graduate students, this book will also be of significant interest to scientists working in or affiliated with this field.
J. Baret, B. Cauli, M. Chabert, V. Abecassis-Taly, P. Dittrich, E. Fort, ... Royal Society of Chemistry, Unravelling Single Cell Genomics, The Royal Society of Chemistry, 2010.
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Digital access
$171.00
Print format
Unravelling Single Cell Genomics
$171.00
Table of contents
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An Introduction to Molecular Biologyp1-14ByLuce DauphinotLuce DauphinotCRICM, CNRS UMR7225, INSERM UHRS975, UPHCHôpital de la Pitié SalpétrièreParisFranceSearch for other works by this author on:
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Chapter 2: The Central Dogma in Molecular Biologyp15-25ByLaili MahmoudianLaili MahmoudianCRICM, UPMC – INSERM URMS975 – CNRS UMR7225, Hôpital de la Pitié SalpétrièreParisFranceSearch for other works by this author on:
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Chapter 3: From Unicellular to Multicellular Organisms∶ Tells from Evolution and from Developmentp26-35ByTania VitalisTania VitalisCNRS-UMR 7637, Laboratoire de NeurobiologieESPCI, 10 rue Vauquelin, 75005ParisFranceSearch for other works by this author on:
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Chapter 4: Understanding Cellular Differentiationp36-44ByTania VitalisTania VitalisCNRS-UMR 7637Laboratoire de Neurobiologie et Diversité Cellulaire, ESPCI, 10 rue Vauquelin, 75005ParisFranceSearch for other works by this author on:
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Chapter 5: Realistic Models of Neurons Require Quantitative Information at the Single-cell Levelp45-53ByNicolas Le NovèreNicolas Le NovèreEMBL-EBIWellcome-Trust Genome Campus, Hinxton CB10 1SDUKSearch for other works by this author on:
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Chapter 6: Application to Cancerogenesis: Towards Targeted Cancer Therapies?p54-60ByBernhard Polzer;Bernhard PolzerDivision of OncogenomicsUniversity of Regensburg, Franz-Josef-Strauss-Allee 1193053 RegensburgGermanySearch for other works by this author on:Christoph A. KleinChristoph A. KleinDivision of OncogenomicsUniversity of Regensburg, Franz-Josef-Strauss-Allee 1193053 RegensburgGermanySearch for other works by this author on:
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Chapter 7: Capturing a Single Cellp61-72ByCatherine Rey;Catherine ReyGenomic and microgenomic core facility: ProfileXpert platform (Federative Institute of Neurosciences)16 rue du Doyen Lépine, 69676 Bron cedexFranceInstitut Fédératif des NeurosciencesIFNL, F-69676 BronFranceSearch for other works by this author on:Anne Wierinckx;Anne WierinckxGenomic and microgenomic core facility: ProfileXpert platform (Federative Institute of Neurosciences)16 rue du Doyen Lépine, 69676 Bron cedexFranceUniversité de Lyon 1Université Lyon 1, Inserm U842, F-69372 LyonFranceSearch for other works by this author on:Séverine Croze;Séverine CrozeGenomic and microgenomic core facility: ProfileXpert platform (Federative Institute of Neurosciences)16 rue du Doyen Lépine, 69676 Bron cedexFranceSearch for other works by this author on:Catherine Legras-Lachuer;Catherine Legras-LachuerGenomic and microgenomic core facility: ProfileXpert platform (Federative Institute of Neurosciences)16 rue du Doyen Lépine, 69676 Bron cedexFranceUniversité de Lyon, INRA, UMR754, Université Lyon 1Ecole Nationale Vétérinaire de Lyon, Ecole Pratique des Hautes Etudes, IFR 128, 50 avenue Tony Garnier, F-69366 Lyon, cedex 07FranceSearch for other works by this author on:Joel LachuerJoel LachuerGenomic and microgenomic core facility: ProfileXpert platform (Federative Institute of Neurosciences)16 rue du Doyen Lépine, 69676 Bron cedexFranceUniversité de Lyon 1Université Lyon 1, Inserm U842, F-69372 LyonFranceSearch for other works by this author on:
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Chapter 8: Looking at the DNA of a Single Cellp73-80ByBernhard Polzer;Bernhard PolzerDivision of Oncogenomics, University of RegensburgFranz-Josef-Strauss-Allee 11, 93053 RegensburgGermanySearch for other works by this author on:Christoph A. KleinChristoph A. KleinDivision of Oncogenomics, University of RegensburgFranz-Josef-Strauss-Allee 11, 93053 RegensburgGermanySearch for other works by this author on:
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Chapter 9: Gene Analysis of Single Cellsp81-92ByBruno Cauli;Bruno CauliUniversité Pierre et Marie Curie Paris 6CNRS UMR7102, Neurobiologie des Processus Adaptatif, 9 quai saint Bernard75005 ParisFranceSearch for other works by this author on:Bertrand LambolezBertrand LambolezUniversité Pierre et Marie Curie Paris 6CNRS UMR7102, Neurobiologie des Processus Adaptatif, 9 quai saint Bernard75005 ParisFranceSearch for other works by this author on:
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Chapter 10: Proteomicsp93-110ByAnne-Marie Hesse;Anne-Marie HesseBiological Mass Spectrometry and ProteomicsUSR 3149 CNRS/ESPCI ParisTech, Ecole Superieure de Physique et de Chimie Industrielles, 10 rue Vauquelin, 75231 Paris cedex 05FranceSearch for other works by this author on:Joëlle VinhJoëlle VinhBiological Mass Spectrometry and ProteomicsUSR 3149 CNRS/ESPCI ParisTech, Ecole Superieure de Physique et de Chimie Industrielles, 10 rue Vauquelin, 75231 Paris cedex 05FranceSearch for other works by this author on:
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Chapter 11: Microfluidics: Basic Concepts and Microchip Fabricationp111-149ByConni Vollrath;Conni VollrathDepartment of Chemistry and Applied BiosciencesWolfgang-Pauli-Str. 10, CH-8093 ZurichSwitzerlandSearch for other works by this author on:Petra S. DittrichPetra S. DittrichDepartment of Chemistry and Applied BiosciencesWolfgang-Pauli-Str. 10, CH-8093 ZurichSwitzerlandSearch for other works by this author on:
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Chapter 12: Cell Capture and Lysis on a Chipp150-184BySéverine Le Gac;Séverine Le GacBIOs The Lab-on-a-Chip Group, University of TwenteP.O. Box 217, 7500 AE EnschedeThe NetherlandsSearch for other works by this author on:Albert van den BergAlbert van den BergBIOs The Lab-on-a-Chip Group, University of TwenteP.O. Box 217, 7500 AE EnschedeThe NetherlandsSearch for other works by this author on:
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Chapter 13: DNA Analysis in Microfluidic Devices and their Application to Single Cell Analysisp185-195ByYann Marcy;Yann MarcyGenewave172 rue de Charonne75011 ParisFranceSearch for other works by this author on:Angélique Le BrasAngélique Le BrasGenewave172 rue de Charonne75011 ParisFranceSearch for other works by this author on:
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Chapter 14: Gene Expression Analysis on Microchipsp196-208ByMax ChabertMax ChabertRHODIA Lab of the FutureF-33608 Pessac CedexFranceSearch for other works by this author on:
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Chapter 15: Analysis of Proteins at the Single Cell Levelp209-242BySéverine Le GacSéverine Le GacBIOS the Lab-on-a-Chip groupUniversity of Twente, P.O. Box 217, 7500 AE EnschedeThe NetherlandsSearch for other works by this author on:
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Chapter 16: A Concrete Case: A Microfluidic Device for Single Cell Whole Transcriptome Analysisp243-260ByNathalie Bontoux;Nathalie BontouxCRICM, CNRS UMR7225, INSERM, URMS975, UPMCHôpital de la Pitié SalpétrièreParisFranceSearch for other works by this author on:Luce Dauphinot;Luce DauphinotCRICM, CNRS UMR7225, INSERM, URMS975, UPMCHôpital de la Pitié SalpétrièreParisFranceSearch for other works by this author on:Marie-Claude PotierMarie-Claude PotierCRICM, CNRS UMR7225, INSERM, URMS975, UPMCHôpital de la Pitié SalpétrièreParisFranceSearch for other works by this author on:
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Chapter 17: Tiny Droplets for High-throughput Cell-based Assaysp261-284ByJ.-C. Baret;J.-C. BaretInstitut de Science et d’Ingénierie Supramoléculaires (ISIS), Université de StrasbourgCNRS UMR 7006StrasbourgFranceSearch for other works by this author on:V. TalyV. TalyInstitut de Science et d’Ingénierie Supramoléculaires (ISIS), Université de StrasbourgCNRS UMR 7006StrasbourgFranceSearch for other works by this author on:
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Chapter 18: New Detection Methods for Single Cellsp285-309ByEmmanuel FortEmmanuel FortCentre d’Imageries Plasmoniques Appliquées, Institut LangevinESPCI ParisTech, CNRS UMR 7587, Université Paris Diderot, 10 rue Vauquelin, 75 231 Paris Cedex 05FranceSearch for other works by this author on:
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