Unravelling Single Cell Genomics
Chapter 6: Application to Cancerogenesis: Towards Targeted Cancer Therapies?
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Published:18 Oct 2010
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Special Collection: 2010 ebook collection , 2010 ebook collection , 2010 materials and nanoscience subject collectionSeries: Nanoscience & Nanotechnology
Bernhard Polzer, Christoph A. Klein, 2010. "Application to Cancerogenesis: Towards Targeted Cancer Therapies?", Unravelling Single Cell Genomics, Jean-Christophe Baret, Bruno Cauli, Max Chabert, Valerie Abecassis-Taly, Petra Dittrich, Emmanuel Fort, Christoph Klein, Joel Lachuer, Bertrand Lambolez, Nicholas Le Novere, Severine le Gac, Laili Mahmoudian, Yann Marcy, Bernhard Polzer, Joelle Vinh, Tania Vitalis, Nathalie Bontoux, Marie-Claude Potier, Luce Dauphinot, Harold Craighead, Harry Kroto, Paul O'Brien, Royal Society of Chemistry
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Although molecular diagnosis in cancer has advanced over the last decades translation into successful therapies of solid cancers is lagging behind. In this chapter we will provide insights into the molecular analysis of single disseminated tumour cells (DTCs) – a cell population that comprises the founder cells of lethal metastasis. Here, recent data challenge the traditional approach of using the primary tumour as the surrogate marker for the selection of adjuvant therapies and emphasize the need to understand the biology of systemic cancer progression for personalized targeted therapies.
