Unravelling Single Cell Genomics
Chapter 4: Understanding Cellular Differentiation
Published:18 Oct 2010
Special Collection: 2010 ebook collection , 2010 ebook collection , 2010 materials and nanoscience subject collectionSeries: Nanoscience & Nanotechnology
Tania Vitalis, 2010. "Understanding Cellular Differentiation", Unravelling Single Cell Genomics, Jean-Christophe Baret, Bruno Cauli, Max Chabert, Valerie Abecassis-Taly, Petra Dittrich, Emmanuel Fort, Christoph Klein, Joel Lachuer, Bertrand Lambolez, Nicholas Le Novere, Severine le Gac, Laili Mahmoudian, Yann Marcy, Bernhard Polzer, Joelle Vinh, Tania Vitalis, Nathalie Bontoux, Marie-Claude Potier, Luce Dauphinot, Harold Craighead, Harry Kroto, Paul O'Brien, Royal Society of Chemistry
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Developmental biology is making tremendous progress in describing the mechanisms that coordinate developmental programs and lead to the specification and differentiation of the correct cell at the correct position with appropriate synaptic or cell–cell contacts. In parallel, progress in microscale and nanoscale technologies and microfluidics is revealing new insights into single cell development in a specific environment. With these approaches it becomes possible to pinpoint the master genes that control the specification and differentiation of a single cell. In addition, these new technologies are also providing means to control microenvironments and possibly direct cell differentiation. They could also be valuable in understanding the role of a cell environment versus the genetic determinants. To revue what micro and nano-tools could offer to understand development, we will focus on the development of the nervous system.