Chapter 13: Carbohydrate-based dendrimers
Published:20 Mar 2014
L. L’Haridon and J. Mallet, in Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40, ed. A. Pilar Rauter, T. Lindhorst, and Y. Queneau, The Royal Society of Chemistry, 2014, vol. 40, ch. 13, pp. 257-269.
Download citation file:
This review is devoted to the description of synthetic strategies for glycodendrimers synthesis. Dendrimers can be classified into three categories: carbohydrate-coated, carbohydrate-centered and carbohydrate-based dendrimer. In this paper we will focus on the third one, in which the core unit is originated from a monosaccharide. Compare to classical Pamam, Boltorn cores, carbohydrate units add much more three dimension information, coded in the chirality in almost each carbon. Various coupling chemistry have been developed and are presented here: glycosylation, amide bound formation, and click chemistry (thiol-ene reaction, epoxide – thiol reaction).