Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40
Chapter 21: Sugar decorated receptors for chiral anions
Published:20 Mar 2014
Jarosław M. Granda, Janusz Jurczak, 2014. "Sugar decorated receptors for chiral anions", Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40, Amelia Pilar Rauter, Thisbe Lindhorst, Yves Queneau
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In this contribution, we present anion receptors possessing binding pocket modified with monosaccharides. We also discuss how incorporation of a sugar into host backbone affect structural and binding properties of anion receptors, what is exemplified by recognition of achiral anions. Following important factors in design of chiral receptors, are also discussed – geometry and topology of anion binding pocket as well as the role of sugar moiety in recognition processes. Application of sugar containing receptors in chiral recognition of biologically important anions such as α-hydroxy and α-amino acids are presented.