Chapter 25: Development of cancer vaccines from fully synthetic mucin-based glycopeptide antigens. A vision on mucins from the bioorganic chemistry perspective
Published:20 Mar 2014
A. Fernández-Tejada and S. J. Danishefsky, in Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40, ed. A. Pilar Rauter, T. Lindhorst, and Y. Queneau, The Royal Society of Chemistry, 2014, vol. 40, ch. 25, pp. 533-563.
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This chapter summarizes powerful chemical strategies for the synthesis of mucin-type glycopeptides with special emphasis on the cassette assembly approach applied in our laboratory. The review will focus mainly on efforts by our research group towards the preparation of fully synthetic mucin-based cancer vaccines of clinical value, while briefly acknowledging other key actors in the field.