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SPR Carbohydrate Chemistry
Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40
Edited by
Amelia Pilar Rauter;
Amelia Pilar Rauter
Universidade de Lisboa, Portugal
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Thisbe Lindhorst;
Thisbe Lindhorst
Kiel University, Germany
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Yves Queneau
Yves Queneau
INSA Lyon, France
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Volume
40
Hardback ISBN:
978-1-84973-965-8
PDF ISBN:
978-1-84973-998-6
EPUB ISBN:
978-1-78262-129-4
No. of Pages:
670
Publication date:
20 Mar 2014
Book Chapter
Chapter 25: Development of cancer vaccines from fully synthetic mucin-based glycopeptide antigens. A vision on mucins from the bioorganic chemistry perspective
By
Alberto Fernández-Tejada
;
Alberto Fernández-Tejada
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research
1275 York Avenue, New York
New York
10065
United States
[email protected]
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Samuel J. Danishefsky
Samuel J. Danishefsky
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research
1275 York Avenue, New York
New York
10065
United States
[email protected]Department of Chemistry, Columbia University
3000 Broadway, New York
New York
10027
United States
[email protected]
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Published:20 Mar 2014
-
Page range:
533 - 563
Citation
A. Fernández-Tejada and S. J. Danishefsky, in Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40, ed. A. Pilar Rauter, T. Lindhorst, and Y. Queneau, The Royal Society of Chemistry, 2014, vol. 40, ch. 25, pp. 533-563.
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This chapter summarizes powerful chemical strategies for the synthesis of mucin-type glycopeptides with special emphasis on the cassette assembly approach applied in our laboratory. The review will focus mainly on efforts by our research group towards the preparation of fully synthetic mucin-based cancer vaccines of clinical value, while briefly acknowledging other key actors in the field.
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