Singlet Oxygen: Applications in Biosciences and Nanosciences
Chapter 11: Endogenous Singlet Oxygen Photosensitizers in Mammalians
Published:27 Jan 2016
Special Collection: 2016 ebook collection
W. Bäumler, in Singlet Oxygen: Applications in Biosciences and Nanosciences, ed. S. Nonell, C. Flors, S. Nonell, and C. Flors, The Royal Society of Chemistry, 2016, ch. 11, pp. 225-238.
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Mammalians are frequently exposed to different radiation sources that emit different spectra ranging from the ultraviolet to the infrared. The cells of tissue contain various molecules and some of them may act as endogenous photosensitizers. These specific molecules transfer the absorbed radiation to molecular oxygen that is excited from its ground state to the first singlet state generating highly reactive singlet oxygen (1O2). 1O2 is an important biochemical intermediate in multiple biological processes. Most of the known endogenous photosensitizers generate 1O2 with UVA and partially with visible irradiation. However, many of these photosensitizers also absorb UVB radiation, sometimes to a higher extent as compared to UVA or visible radiation. Thus, UVB-induced 1O2 might play an additional, important role for the mechanisms of oxidative tissue damage. Endogenous photosensitizers may change its chemical structure under UV irradiation that may affect 1O2 generation.