Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 41
Carbohydrate–carbohydrate interaction: from hypothesis to confirmation
Published:02 Dec 2015
Y. Zhang, D. Lu, M. Sollogoub, and Y. Zhang, in Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 41, ed. A. Pilar Rauter, T. K. Lindhorst, and Y. Queneau, The Royal Society of Chemistry, 2015, vol. 41, pp. 238-254.
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Carbohydrates play important roles in a wide range of biological processes. Since the first hypothesis about carbohydrate–carbohydrate interaction (CCI) was proposed by Hakomori et al., an increasing interest has been placed on CCI, using a variety of techniques. Based on all these studies, Lewisx–Lewisx interaction (a typical CCI) has been now confirmed to be specific, homotypic, and mediated by the presence of divalent cations such as Ca2+. In this review, a detailed overview of the process from hypothesis to confirmation of carbohydrate–carbohydrate interaction is summarized.