DNA Damage, DNA Repair and Disease: Volume 1
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
DNA Damage, DNA Repair and Disease: Volume 1, The Royal Society of Chemistry, 2020.
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Chapter 1: Biomonitoring of DNA Damage in Humansp1-26ByJ. Guo;J. GuoMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota2231 6th St. SEMinneapolisMinnesota55455USA[email protected]Search for other works by this author on:B. H. Yun;B. H. YunMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota2231 6th St. SEMinneapolisMinnesota55455USA[email protected]Search for other works by this author on:R. J. TureskyR. J. TureskyMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota2231 6th St. SEMinneapolisMinnesota55455USA[email protected]Search for other works by this author on:
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Chapter 2: Tandem and Clustered Lesions from Radicals in Nucleic Acids from a Single Initial Chemical Eventp27-60ByM. M. GreenbergM. M. GreenbergJohns Hopkins University, Department of Chemistry3400 N. Charles St., NCB 313BaltimoreMD 21218USA[email protected]Search for other works by this author on:
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Chapter 3: Oxidative DNA Damage and Repair in G-quadruplexesp61-85ByA. M. Fleming;A. M. FlemingDepartment of Chemistry, University of Utah315 S. 1400 EastSalt Lake CityUT 84112-0850USA[email protected]Search for other works by this author on:S. C. J. Redstone;S. C. J. RedstoneDepartment of Chemistry, University of Utah315 S. 1400 EastSalt Lake CityUT 84112-0850USA[email protected]Search for other works by this author on:C. J. BurrowsC. J. BurrowsDepartment of Chemistry, University of Utah315 S. 1400 EastSalt Lake CityUT 84112-0850USA[email protected]Search for other works by this author on:
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Chapter 4: Oxidatively Induced DNA Damage: Mechanisms and Measurementp86-116ByM. Dizdaroglu;M. DizdarogluBiomolecular Measurement Division, National Institute of Standards and Technology100 Bureau Drive, MS 8315GaithersburgMD 20899USA[email protected]Search for other works by this author on:E. Coskun;E. CoskunBiomolecular Measurement Division, National Institute of Standards and Technology100 Bureau Drive, MS 8315GaithersburgMD 20899USA[email protected]Institute for Bioscience & Biotechnology Research, University of Maryland9600 Gudelsky DriveRockvilleMD 20850USASearch for other works by this author on:G. Tuna;G. TunaDepartment of Molecular Medicine, Institute of Health Sciences, Dokuz Eylul UniversityIzmirTurkeySearch for other works by this author on:M. Kant;M. KantBiomolecular Measurement Division, National Institute of Standards and Technology100 Bureau Drive, MS 8315GaithersburgMD 20899USA[email protected]Search for other works by this author on:P. JarugaP. JarugaBiomolecular Measurement Division, National Institute of Standards and Technology100 Bureau Drive, MS 8315GaithersburgMD 20899USA[email protected]Search for other works by this author on:
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Chapter 5: Oxidation of the C5′ Position in DNA and the Role of Purine 5′,8-Cyclo-2′-deoxynucleoside Lesionsp117-139ByM. G. Krokidis;M. G. KrokidisInstitute of Nanoscience and NanotechnologyN.C.S.R. “Demokritos”15310 Agia Paraskevi AttikisAthensGreeceSearch for other works by this author on:A. MasiA. MasiSearch for other works by this author on:
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Chapter 6: Ferroptosis and Oxidative DNA Damagep140-153ByS. Toyokuni;S. ToyokuniDepartment of Pathology and Biological Responses, Nagoya University Graduate School of medicine65 Tsurumai-choShowa-kuNagoya 466-8550Japan[email protected]Search for other works by this author on:I. YanatoriI. YanatoriDepartment of Pathology and Biological Responses, Nagoya University Graduate School of medicine65 Tsurumai-choShowa-kuNagoya 466-8550Japan[email protected]Search for other works by this author on:
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Chapter 7: DNA–Protein Cross-links: Formation, Genotoxicity and Repairp154-174ByC. Campbell;C. CampbellDepartment of Pharmacology, University of MinnesotaMinneapolisMNUSASearch for other works by this author on:N. Y. TretyakovaN. Y. TretyakovaMasonic Cancer Center and Department of Medicinal Chemistry, University of MinnesotaMinneapolisMNUSASearch for other works by this author on:
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Chapter 8: Substrate Specificities of DNA Glycosylases In Vitro and In Vivop175-203ByA. V. Endutkin;A. V. EndutkinSB RAS Institute of Chemical Biology and Fundamental Medicine8 Lavrentieva Ave.Novosibirsk 630090Russia[email protected]Search for other works by this author on:D. O. ZharkovD. O. ZharkovSB RAS Institute of Chemical Biology and Fundamental Medicine8 Lavrentieva Ave.Novosibirsk 630090Russia[email protected]Novosibirsk State University2 Pirogova St.Novosibirsk 630090RussiaSearch for other works by this author on:
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Chapter 9: Special Problems for Base Excision Repair in Coping with Oxidatively-induced DNA Damagep204-219ByB. DempleB. DempleSearch for other works by this author on:
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Chapter 10: Genomic Uracil in Biology, Immunity and Cancerp220-248ByB. Kavli;B. KavliDepartment of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and TechnologyNO-7491TrondheimNorway[email protected]Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University HospitalNorwaySearch for other works by this author on:G. Slupphaug;G. SlupphaugDepartment of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and TechnologyNO-7491TrondheimNorway[email protected]Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University HospitalNorwayPROMEC Proteomics and Modomics Experimental Core at NTNU and the Regional Health Authority of Mid-NorwayNorwaySearch for other works by this author on:H. E. KrokanH. E. KrokanDepartment of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and TechnologyNO-7491TrondheimNorway[email protected]Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University HospitalNorwaySearch for other works by this author on:
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Chapter 11: Alternative DNA Repair Pathways to Handle Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugsp249-278ByE. Matta;E. MattaGroupe «Réparation de l'ADN», Equipe Labellisée LIGUE Contre le Cancer 2016, CNRS UMR9019, Université Paris-Sud, Gustave Roussy Cancer CampusF-94805 Villejuif CedexFrance[email protected][email protected]Search for other works by this author on:U. Aliyaskarova;U. AliyaskarovaGroupe «Réparation de l'ADN», Equipe Labellisée LIGUE Contre le Cancer 2016, CNRS UMR9019, Université Paris-Sud, Gustave Roussy Cancer CampusF-94805 Villejuif CedexFrance[email protected][email protected]Search for other works by this author on:A. A. Kuznetsova;A. A. KuznetsovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia[email protected]Search for other works by this author on:B. T. Matkarimov;B. T. MatkarimovNational Laboratory Astana, Nazarbayev UniversityNur-Sultan 010000KazakhstanSearch for other works by this author on:O. S. Fedorova;O. S. FedorovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia[email protected]Search for other works by this author on:N. A. Kuznetsov;N. A. KuznetsovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia[email protected]Search for other works by this author on:A. A. Ishchenko;A. A. IshchenkoGroupe «Réparation de l'ADN», Equipe Labellisée LIGUE Contre le Cancer 2016, CNRS UMR9019, Université Paris-Sud, Gustave Roussy Cancer CampusF-94805 Villejuif CedexFrance[email protected][email protected]Search for other works by this author on:M. SaparbaevM. SaparbaevGroupe «Réparation de l'ADN», Equipe Labellisée LIGUE Contre le Cancer 2016, CNRS UMR9019, Université Paris-Sud, Gustave Roussy Cancer CampusF-94805 Villejuif CedexFrance[email protected][email protected]Search for other works by this author on:
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Chapter 12: Redox Stress Responses and Human Disease: NTHL1 at the Intersection of DNA Damage Repair and Cancerp279-300ByA. Kar;A. KarMutagenesis and DNA Repair Regulation Group, Laboratory of Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of HealthDurhamNorth CarolinaUSA[email protected]Search for other works by this author on:N. P. Degtyareva;N. P. DegtyarevaMutagenesis and DNA Repair Regulation Group, Laboratory of Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of HealthDurhamNorth CarolinaUSA[email protected]Search for other works by this author on:P. W. DoetschP. W. DoetschMutagenesis and DNA Repair Regulation Group, Laboratory of Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of HealthDurhamNorth CarolinaUSA[email protected]Search for other works by this author on:
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Chapter 13: Emerging Roles of Non-canonical RNA Binding Proteins in the Repair of Genome Damage Linked to Human Pathologiesp301-322ByJ. Mitra;J. MitraDepartment of Radiation Oncology, Houston Methodist Research InstituteHoustonTexas 77030USA[email protected][email protected]Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research InstituteHoustonTexas 77030USASearch for other works by this author on:H. Wang;H. WangDepartment of Radiation Oncology, Houston Methodist Research InstituteHoustonTexas 77030USA[email protected][email protected]Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research InstituteHoustonTexas 77030USASearch for other works by this author on:M. Kodavati;M. KodavatiDepartment of Radiation Oncology, Houston Methodist Research InstituteHoustonTexas 77030USA[email protected][email protected]Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research InstituteHoustonTexas 77030USASearch for other works by this author on:S. Mitra;S. MitraDepartment of Radiation Oncology, Houston Methodist Research InstituteHoustonTexas 77030USA[email protected][email protected]Weill Medical College of Cornell UniversityNew YorkUSASearch for other works by this author on:M. L. HegdeM. L. HegdeDepartment of Radiation Oncology, Houston Methodist Research InstituteHoustonTexas 77030USA[email protected][email protected]Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research InstituteHoustonTexas 77030USAWeill Medical College of Cornell UniversityNew YorkUSASearch for other works by this author on:
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Chapter 14: Modulation of DNA Glycosylase Activities via Small Moleculesp323-347ByA. K. McCullough;A. K. McCulloughOregon Institute of Occupational Health Sciences, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USA[email protected]Department of Molecular and Medical Genetics, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USASearch for other works by this author on:I. G. Minko;I. G. MinkoOregon Institute of Occupational Health Sciences, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USA[email protected]Search for other works by this author on:A. Nilsen;A. NilsenDepartment of Chemical Physiology and Biochemistry, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USASearch for other works by this author on:S. Nagarajan;S. NagarajanDepartment of Chemical Physiology and Biochemistry, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USASearch for other works by this author on:R. S. LloydR. S. LloydOregon Institute of Occupational Health Sciences, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USA[email protected]Department of Molecular and Medical Genetics, Oregon Health & Sciences University3181 SW Sam Jackson Park RdPortlandOR 97239USASearch for other works by this author on:
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Chapter 15: DNA Repair in the Development of Human Diseases and Therapyp348-378ByM. D'Errico;M. D'ErricoDepartment of Environment and Health, Istituto Superiore di SanitàViale Regina Elena 29900161 RomeItaly[email protected]Search for other works by this author on:B. Pascucci;B. PascucciDepartment of Environment and Health, Istituto Superiore di SanitàViale Regina Elena 29900161 RomeItaly[email protected]Institute of Cristallography, CNRVia Salaria Km 29.300, Monterotondo00015 RomeItalySearch for other works by this author on:E. Parlanti;E. ParlantiDepartment of Environment and Health, Istituto Superiore di SanitàViale Regina Elena 29900161 RomeItaly[email protected]Search for other works by this author on:V. Simonelli;V. SimonelliDepartment of Environment and Health, Istituto Superiore di SanitàViale Regina Elena 29900161 RomeItaly[email protected]Search for other works by this author on:E. DogliottiE. DogliottiDepartment of Environment and Health, Istituto Superiore di SanitàViale Regina Elena 29900161 RomeItaly[email protected]Search for other works by this author on:
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