Chapter 13: Functionalisation and Self-assembly of Nanoparticles through Cucurbit[n]uril-based Binding Motifs

This chapter focuses on the use of cucurbit[n]urils for the functionalisation and controlled assembly of organic and inorganic nanoparticulate components. We begin by exploring the direct electrostatic interaction of the cucurbit[n]uril rims with metallic nanoparticle surfaces and how this can induce the controlled aggregation of nanoparticles. Use of this interaction in nanoparticle formation, surface enhanced Raman spectroscopy (SERS), catalysis and nanowire formation are discussed within. Cucurbit[n]urils can functionalise nanoparticle surfaces indirectly through complexation with surface-bound ligands. Nanoparticles can be assembled through such indirect functionalisation. If stimuli-responsive guests are used, then controllable assembly and disassembly results, and is discussed in depth. The chapter ends by looking at the use of cucurbit[n]urils in the formation of nanoparticles and colloidosomes through host–guest interactions. This wide range of capabilities makes cucurbit[n]uril-based nanosystems of huge interest for use in triggered assembly and delivery with many further areas yet to be investigated.