Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 45
Recent advances in the functionalization of unprotected carbohydrates
Published:15 Dec 2021
Special Collection: 2021 ebook collection
Angélique Ferry, Florian Gallier, Simon Gonzalez, Nadège Lubin-Germain, Leandro Soter de Mariz e Miranda, Jacques Uziel, 2021. "Recent advances in the functionalization of unprotected carbohydrates", Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 45, Amélia Pilar Rauter, Thisbe K Lindhorst, Yves Queneau
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The development of chemical glycosylation methodologies employing protection-free sugar building blocks is the holy grail of the glycochemistry. Nevertheless, the glycochemists toolbox is mostly composed of synthetic methods applicable only to the protected glycosides. Thus, environmentally friendly chemo, regio and diastereoselective reactions of free glycosides are highly needed. As the present chapter illustrates, many advances in the glycosylation reactions on unprotected glycosides were developed in the last decade. This chapter focusses on the development of chemical and biocatalyzed strategies toward methodologies using unprotected glycosides.