Engineering the Bioelectronic Interface: Applications to Analyte Biosensing and Protein Detection
The interfacing of man-made electronics with redox proteins and enzymes not only tells us a great deal about the levels of sophistication active in biology, but also paves the way to using it in derived sensory devices. Some of these have already had a profound impact on both clinical diagnostics and the quality of life enjoyed by those unfortunate enough to live with disease. Though much remains to be learnt about controlling and optimising these interfacial interactions, their potential uses are, if anything, growing. Written by leaders in the field, this is the only book to focus on the generation of biosensing interfaces with analyses and control at the molecular level. Some of these are enzyme based, others associated with the generation of surfaces for protein-protein recognition. Summaries of state-of-the-art investigations into the interfacing of structurally complex molecular species with electrode surfaces are included along with their design, analysis and potential application. Studies into the "wiring" of biomolecules to man-made surfaces through the use of delocalised "molecular wires" or carbon nanotubes are detailed as are the application of surface chemical and genetic engineering methods to the construction of robust, orientated biomolecular monolayers.
Engineering the Bioelectronic Interface: Applications to Analyte Biosensing and Protein Detection, The Royal Society of Chemistry, 2009.
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Chapter 1: Communication with the Mononuclear Molybdoenzymes: Emerging Opportunities and Applications in Redox Enzyme Biosensorsp1-24ByPaul V. BernhardtPaul V. BernhardtCentre for Metals in Biology, School of Chemistry and Molecular Biosciences, University of QueenslandBrisbane 4072AustraliaSearch for other works by this author on:
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Chapter 2: Scanning Probe Analyses at the Bioelectronic Interfacep25-55ByJason J. Davis;Jason J. DavisChemistry Research Laboratory, University of Oxford, Mansfield RoadOxford OX1 3TAUKSearch for other works by this author on:Ben Peters;Ben PetersChemistry Research Laboratory, University of Oxford, Mansfield RoadOxford OX1 3TAUKSearch for other works by this author on:Yuki Hanyu;Yuki HanyuChemistry Research Laboratory, University of Oxford, Mansfield RoadOxford OX1 3TAUKSearch for other works by this author on:Wang XiWang XiChemistry Research Laboratory, University of Oxford, Mansfield RoadOxford OX1 3TAUKSearch for other works by this author on:
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Chapter 3: Electrical Interfacing of Redox Enzymes with Electrodes by Surface Reconstitution of Bioelectrocatalytic Nanostructuresp56-93ByItamar Willner;Itamar WillnerInstitute of Chemistry, The Hebrew University of JerusalemJerusalem91904IsraelSearch for other works by this author on:Ran Tel-Vered;Ran Tel-VeredInstitute of Chemistry, The Hebrew University of JerusalemJerusalem91904IsraelSearch for other works by this author on:Bilha WillnerBilha WillnerInstitute of Chemistry, The Hebrew University of JerusalemJerusalem91904IsraelSearch for other works by this author on:
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Chapter 4: Single-wall Carbon Nanotube Forests in Biosensorsp94-118ByJames F. Rusling;James F. RuslingDepartment of ChemistryUniversity of ConnecticutStorrsCTInstitute of Materials ScienceUniversity of ConnecticutStorrsCTDepartment of Cell BiologyUniversity of Connecticut Health CenterFarmingtonCTSearch for other works by this author on:Xin Yu;Xin YuDepartment of ChemistryUniversity of ConnecticutStorrsCTSchering Plough CorporationUnionNew JerseySearch for other works by this author on:Bernard S. Munge;Bernard S. MungeSalve Regina UniversityNewportRhode IslandSearch for other works by this author on:Sang N. Kim;Sang N. KimInstitute of Materials ScienceUniversity of ConnecticutStorrsCTSearch for other works by this author on:Fotios PapadimitrakopoulosFotios PapadimitrakopoulosDepartment of ChemistryUniversity of ConnecticutStorrsCTInstitute of Materials ScienceUniversity of ConnecticutStorrsCTSearch for other works by this author on:
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Chapter 5: Activating Redox Enzymes through Immobilisation and Wiringp119-152ByH.A. Heering;H.A. HeeringLeiden UniversityPO Box 95022300 RA LeidenThe NetherlandsSearch for other works by this author on:G.W. CantersG.W. CantersLeiden UniversityPO Box 95022300 RA LeidenThe NetherlandsSearch for other works by this author on:
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Chapter 6: Cytochromes P450: Tailoring a Class of Enzymes for Biosensingp153-192ByVikash R. Dodhia;Vikash R. DodhiaImperial College LondonBiochemistry BuildingSouth KensingtonLondonSW7 2AZUKSearch for other works by this author on:Gianfranco GilardiGianfranco GilardiUniversity of TurinTurinItalySearch for other works by this author on:
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Chapter 7: Label-free Field Effect ProteinSensingp193-224ByJan Tkac;Jan TkacChemistry Research Laboratory, University of OxfordSouth Parks RoadOxfordOX1 3TAUKSearch for other works by this author on:Jason J. DavisJason J. DavisChemistry Research Laboratory, University of OxfordSouth Parks RoadOxfordOX1 3TAUKSearch for other works by this author on:
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Chapter 8: Biological and Clinical Applications of Biosensorsp225-242ByPaul Ko FerrignoPaul Ko FerrignoSection of Experimental Therapeutics, Leeds Institute of Molecular Medicine, St James's University HospitalBeckett StreetLeeds LS9 7TFUKSearch for other works by this author on:
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