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SPR Organometallic Chemistry
Organometallic Chemistry: Volume 40
Edited by
Jason Lynam
Jason Lynam
University of York, UK
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Volume
40
Hardback ISBN:
978-1-84973-984-9
PDF ISBN:
978-1-78262-396-0
EPUB ISBN:
978-1-78262-715-9
Special Collection:
2015 ebook collection
No. of Pages:
198
Publication date:
28 Sep 2015
Book Chapter
Carbon monoxide-releasing molecules: therapeutic molecules with a wide variety of medical applications
By
Jonathan S. Ward
Jonathan S. Ward
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Published:28 Sep 2015
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Special Collection: 2015 ebook collection
Page range:
140 - 176
Citation
J. S. Ward, in Organometallic Chemistry: Volume 40, ed. I. Fairlamb and J. Lynam, The Royal Society of Chemistry, 2015, vol. 40, pp. 140-176.
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In the past 15–20 years, carbon monoxide has been shown to be a key signalling molecule in biological systems. The CO regulatory pathway has been exploited to develop many series of promising new therapeutic molecules for a wide variety of medical applications. This review covers: CO-regulatory pathways, types of CO-releasing molecule, modes and mechanisms of CO-release, and how CO-RM research has developed from using simple structural motifs to complex structures to allow modification of properties.
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