Drug Discovery for Psychiatric Disorders
CHAPTER 8: Beyond SSRIs: Second-generation Reuptake Inhibitors for the Treatment of Depression
Published:08 Oct 2012
Special Collection: 2012 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Drug Discovery
While the selective serotonin reuptake inhibitors (SSRIs) are an improvement over the earlier tricyclic antidepressants, they are limited in their effectiveness and have a unique side-effect profile. In this chapter is an assessment of the serotonin-mediated antidepressant strategies that have been identified from the primary and patent literature. The areas covered include combination serotonin reuptake inhibition and pre- or post-synaptic agonist and antagonist action. New approaches to targeting multiple biogenic amine transporters are discussed, as well as a summary of the stand-alone pre- and post-synaptic agonist and antagonist developments. The chapter focuses on the rationale for the antidepressant targets and the medicinal chemical strategies that have led to the newer molecular platforms.